Enzymes as Targets for Drug Development III
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (30 March 2024) | Viewed by 435
Special Issue Editor
Interests: biochemistry; enzymology; drug discovery; SELEX (systematic evolution of ligands by exponential enrichment); in vitro selection technique
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Enzymes are considered the most attractive targets for drug development in the pharmaceutical community. The characterization of enzymes is, therefore, critical in understanding their reactions. Many analytical methods are needed to complete characterization, such as purification, kinetics, protein stabilization, optimal conditions for pH, temperature, and ionic strength, subtract or product binding, ligand/inhibitor/protein interactions, three-dimensional structure, and conformational changes. Recently, in silico analysis has made a huge contribution to enzyme characterization. Molecular docking and molecular dynamics should be included as major techniques. This Special Issue brings together many intriguing subjects to promote ideas on enzymes or proteins as targets for drug development.
The following topics will be included in the Special Issue:
- Improvement of enzyme/protein purification;
- Development of novel inhibitors;
- Investigation of enzyme mechanism;
- Understanding enzyme conformation changes;
- Understanding protein: ligand interactions by in vitro and/or in silico analyses.
Prof. Dr. Sung-Kun (Sean) Kim
Guest Editor
Manuscript Submission Information
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Keywords
- enzyme kinetics
- enzyme–ligand or protein-protein interactions
- enzyme inhibitions
- enzyme purifications and optimal conditions
- enzyme or protein structures
- enzyme or protein computational analysis
