New Insight: Enzymes as Targets for Drug Development, 2nd Edition
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".
Deadline for manuscript submissions: 31 October 2024 | Viewed by 486
Special Issue Editor
Interests: biochemistry; enzymology; drug discovery; SELEX (systematic evolution of ligands by exponential enrichment); in vitro selection technique
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the pharmaceutical community, the most attractive targets for drug development are enzymes. The characterization of enzymes is critical in understanding their reactions. Many analytical methods are needed to completely characterize them, such as purification; kinetics; protein stabilization; optimal pH conditions; temperature; ionic strength; subtract or product binding; ligand/inhibitor/protein interactions; three-dimensional structure; and conformational changes. Recently, in silico analysis has been successfully used for enzyme characterization. Molecular docking and molecular dynamics should are also major techniques. This Special Issue brings together a large number of intriguing subjects to promote ideas on enzymes as targets for drug development.
The following topics will be included in this Special Issue:
- The improvement of enzyme purification;
- The development of novel inhibitors;
- The investigation of enzyme mechanism;
- Understanding enzyme conformation changes.
Prof. Dr. Sung-Kun (Sean) Kim
Guest Editor
Manuscript Submission Information
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Keywords
- enzyme kinetics
- enzyme–ligand or protein-protein interactions
- enzyme inhibitions
- enzyme purifications and optimal conditions
- enzyme or protein structures
- enzyme or protein computational analysis
