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Advancing Occupational Health Through Omics Technologies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 October 2025 | Viewed by 1435

Special Issue Editor


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Guest Editor
Department of Biomedical and Dental Sciences, Morphological and Functional Imaging, Section of Occupational Medicine, University of Messina, 98125 Messina, Italy
Interests: occupational medicine; work-related diseases; pathology; oncology; pharmacology; toxicology; molecular and cellular biology; biomarkers; drug discovery
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Special Issue Information

Dear Colleagues,

Occupational health risks arise from a complex interplay between chemical, physical, biological, organizational, and psychosocial factors. Traditional biomonitoring approaches, such as the measurement of toxicants and their metabolites in human specimens, play a pivotal role in understanding environmental exposures. However, recent advancements in omics technologies have opened new avenues for personalized worker health analyses. These novel methods, including genomics, epigenomics, transcriptomics, proteomics, and exposomics, provide a comprehensive framework for elucidating the biological mechanisms underlying these health risks. Such approaches facilitate not only the discovery of mechanistic interactions between biological and psychosocial factors but also enable personalized risk assessments tailored to each worker’s unique exposures.

This Special Issue focuses on the application of omics technologies in occupational medicine, emphasizing their potential to revolutionize personalized health assessments and develop intervention strategies for high-risk professions.

We encourage contributions (research articles and reviews) examining a diverse range of occupational exposures. For chemical exposures, research may include toxicants such as benzene, formaldehyde, asbestos, pesticides, and heavy metals like lead and mercury (e.g., in manufacturing, laboratory, and construction environments). Physical factors might involve noise, temperature extremes, ionizing radiation, and exposure to radioactive gasses like radon (e.g., in mining, tunneling, and subway maintenance). Biological hazards could encompass pathogens, allergens, and bioaerosols (e.g., in healthcare, agricultural, and food processing settings). Additionally, organizational factors such as night-shift work, inadequate staffing, and lack of decision-making autonomy significantly impact occupational health by influencing stress levels, mental well-being, and overall worker health. This Special Issue also welcomes studies exploring the molecular mechanisms linking these workplace exposures to disease susceptibility and strategies for prevention tailored to individual biological responses.

Dr. Silvia Vivarelli
Guest Editor

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Keywords

  • omics technologies
  • occupational health
  • biomarkers
  • personalized risk assessment
  • workplace exposures
  • genomics
  • proteomics
  • psychosocial factors
  • disease susceptibility
  • preventive medicine

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Published Papers (1 paper)

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Research

23 pages, 4468 KiB  
Article
Integrated Computational Analysis Reveals Early Genetic and Epigenetic AML Susceptibility Biomarkers in Benzene-Exposed Workers
by Silvia Vivarelli, Cigdem Sevim, Federica Giambò and Concettina Fenga
Int. J. Mol. Sci. 2025, 26(3), 1138; https://doi.org/10.3390/ijms26031138 - 28 Jan 2025
Viewed by 980
Abstract
Benzene, a well-known carcinogenic airborne pollutant, poses significant health risks, particularly in industries such as petroleum, shoemaking, and painting. Despite strict regulations, chronic occupational exposure persists, contributing to the onset of acute myeloid leukemia (AML) and other malignancies. Benzene’s carcinogenicity stems from its [...] Read more.
Benzene, a well-known carcinogenic airborne pollutant, poses significant health risks, particularly in industries such as petroleum, shoemaking, and painting. Despite strict regulations, chronic occupational exposure persists, contributing to the onset of acute myeloid leukemia (AML) and other malignancies. Benzene’s carcinogenicity stems from its metabolic activation, leading to increased oxidative stress, DNA damage, and cancer transformation. While its toxicity is well-documented, the link between genetic and epigenetic alterations and cancer susceptibility in exposed workers remains underexplored. This study aims to identify early biomarkers of benzene exposure and AML risk by analyzing gene expression and DNA methylation datasets from GEO DataSets, integrated with molecular pathway analyses, as well as miRNA-target and protein-protein network evaluations. This multi-approach led to the identification of nine deregulated genes (CRK, CXCR6, GSPT1, KPNA1, MECP2, MELTF, NFKB1, TBC1D7, ZNF331) in workers exposed to benzene, with NFKB1 showing strong discriminatory potential. Also, dose-dependent DNA methylation changes were observed in CXCR6 and MELTF, while selected miRNAs such as let-7d-5p, miR-126-3p, and miR-361-5p emerged as key post-transcriptional regulators. Furthermore, functional enrichment linked these genes to immune response, inflammation, cell proliferation, and apoptosis pathways. While network analyses highlighted NFKB1, CRK, and CXCR6 as central to benzene-associated leukemogenesis. Altogether, these findings provide novel insights into an early biomarker fingerprint for benzene exposure and AML susceptibility, supporting the future development of biomolecular-based targeted occupational health monitoring and personalized preventive strategies for at-risk workers. Full article
(This article belongs to the Special Issue Advancing Occupational Health Through Omics Technologies)
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