Translational Advances in Alzheimer's, Parkinson's, and Other Dementia: Molecular Mechanisms, Biomarkers, Diagnosis, and Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1389
Special Issue Editor
Special Issue Information
Dear Colleagues,
Despite intense research into Alzheimer’s disease (AD) and other dementias, there is no drug that effectively intervenes in the pathogenesis of the disease. Dementia and other neurodegenerative diseases that affect memory, cognition, and behavior are public health priorities throughout the developed world. It is estimated that the number of people with dementia will double every 20 years. Most cases of AD are sporadic; less than 5% carry mutations affecting amyloid beta, and are early-onset familial AD that occur before the age of 65 years. By far the most pressing challenge is to distinguish the different forms of dementia or its early stages from the features of normal brain aging. In the case of vascular dementia, it may be possible to implement prevention strategies based on the closer and more accurate control of vascular risk factors. In the case of degenerative dementia, the exact molecular mechanisms leading to dementia are not well understood, although several mechanisms have been hypothesized at the cellular and neural network levels. Many research approaches may be applicable to the prevention and treatment of dementia, such as the identification of pathogenic compounds (toxins), the search for new targets, the development of new drugs through drug screening or drug design, cell or organelle therapy and device development (single/multiple targets), and other creative and innovative unconventional approaches.
This Special Issue will feature original research articles exploring the molecular mechanisms of dementia disorders from the above aspects, or comprehensive review articles covering these specific topics.
Dr. Avinash Gothwal
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Alzheimer’s disease
- Parkinson’s disease
- dementia
- molecular mechanisms
- biomarkers
- diagnosis
