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Advanced Degradable Biopolymers
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Advanced Degradable Biopolymers

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 10513

Special Issue Editor

Prof. Dr. Tatiana Volova

E-Mail Website
Guest Editor
Institute of Biophysics SB RAS, Federal Research Center “Krasnoyarsk Science Center SB RAS”, 50/50 Akademgorodok, 660036 Krasnoyarsk, Russia
Interests: physiology and biotechnology of microorganisms; producers of target products; producing biosystems; protein synthesis of single-celled, degradable bioplastics of polyhydroxyalkanoates (PHA); structure and properties of PHA, processing into polymer products by electrospinning, 3D printing, cold pressing, and from melts; areas of application—tissue engineering, reconstructive surgery, matrices for the deposition of drugs and preparations for the protection of cultivated plants
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

The development, study, and application of biodegradable polymeric materials are critical technologies of the 21st century. The need to expand the areas of application of biodegradable materials and increase production volumes is due to the widespread accumulation in the biosphere of non-destructible synthetic plastics, the production volumes of which have exceeded 380 mol. tons per year, and the accumulation of which in the biosphere creates a global environmental problem. The source for obtaining destructible biomaterials of various structures is a variety of natural raw materials of plant and animal origin, as well as biotechnological synthesis processes. This Special Issue on “Advanced Degradable Biopolymers” invites manuscripts characterizing various types of biodegradable biomaterials obtained from natural sources and also synthesized in biotechnology processes; new data on production technologies, structure and properties of biomaterials and composites based on them; and new fields of application.

Prof. Dr. Tatiana Volova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biodegradable biopolymers
  • bacterial nanocellulose
  • microbial polyhydroxyalkanoates
  • carrageenan
  • silk sericin
  • synthesis
  • composite
  • properties
  • applications
  • drug delivery system
  • biomedicine
  • wound dressings
  • bioluminescent microanalysis

Published Papers (7 papers)

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Research

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26 pages, 9460 KiB  
Article
Characteristics of Microparticles Based on Resorbable Polyhydroxyalkanoates Loaded with Antibacterial and Cytostatic Drugs
by Anastasiya V. Murueva, Anna M. Shershneva, Ekaterina I. Shishatskaya and Tatiana G. Volova
Int. J. Mol. Sci. 2023, 24(19), 14983; https://doi.org/10.3390/ijms241914983 - 7 Oct 2023
Viewed by 1051
Abstract
The development of controlled drug delivery systems, in the form of microparticles, is an important area of experimental pharmacology. The success of the design and the quality of the obtained microparticles are determined by the method of manufacture and the properties of the [...] Read more.
The development of controlled drug delivery systems, in the form of microparticles, is an important area of experimental pharmacology. The success of the design and the quality of the obtained microparticles are determined by the method of manufacture and the properties of the material used as a carrier. The goal is to obtain and characterize microparticles depending on their method of preparation, the chemical composition of the polymer and the load of the drugs. To obtain microparticles, four types of degradable PHAs, differing in their chemical compositions, degrees of crystallinity, molecular weights and temperature characteristics, were used (poly-3-hydroxybutyrate and copolymers 3-hydroxybutyric-co-3-hydroxyvaleric acid, 3-hydroxybutyric-co-4-hydroxybutyric acid, and 3-hydroxybutyric-co-3-hydroxyhexanoic acid). The characteristics of microparticles from PHAs were studied. Good-quality particles with an average particle diameter from 0.8 to 65.0 μm, having satisfactory ζ potential values (from −18 to −50 mV), were obtained. The drug loading content, encapsulation efficiency and in vitro release were characterized. Composite microparticles based on PHAs with additives of polyethylene glycol and polylactide-co-glycolide, and loaded with ceftriaxone and 5-fluorouracil, showed antibacterial and antitumor effects in E. coli and HeLa cultures. The results indicate the high potential of PHAs for the design of modern and efficient drug delivery systems. Full article
(This article belongs to the Special Issue Advanced Degradable Biopolymers)
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18 pages, 1769 KiB  
Article
Properties of Degradable Polyhydroxyalkanoates Synthesized from New Waste Fish Oils (WFOs)
by Natalia O. Zhila, Evgeniy G. Kiselev, Vladimir V. Volkov, Olga Ya. Mezenova, Kristina Yu. Sapozhnikova, Ekaterina I. Shishatskaya and Tatiana G. Volova
Int. J. Mol. Sci. 2023, 24(19), 14919; https://doi.org/10.3390/ijms241914919 - 5 Oct 2023
Cited by 1 | Viewed by 1016
Abstract
The synthesis of PHA was first investigated using WFOs obtained from smoked-sprat heads, substandard fresh sprats, and fresh mackerel heads and backbones. All the WFOs ensured the growth of the wild-type strain Cupriavidus necator B-10646 and the synthesis of PHA, regardless of the [...] Read more.
The synthesis of PHA was first investigated using WFOs obtained from smoked-sprat heads, substandard fresh sprats, and fresh mackerel heads and backbones. All the WFOs ensured the growth of the wild-type strain Cupriavidus necator B-10646 and the synthesis of PHA, regardless of the degree of lipid saturation (from 0.52 to 0.65) and the set and ratio of fatty acids (FA), which was represented by acids with chain lengths from C14 to C24. The bacterial biomass concentration and PHA synthesis were comparable (4.1–4.6 g/L and about 70%) when using WFO obtained from smoked-sprat heads and fresh mackerel, and it was twice as high as the bacterial biomass concentration from the fresh sprat waste. This depended on the type of WFO, the bacteria synthesized P(3HB) homopolymer or P(3HB-co-3HV-co-3HHx) copolymer, which had a lower degree of crystallinity (Cx 71%) and a lower molecular weight (Mn 134 kDa) compared to the P(3HB) (Mn 175–209 kDa and Cx 74–78%) at comparable temperatures (Tmelt and Tdegr of 158–168 °C and 261–284 °C, respectively). The new types of WFO, studied for the first time, are suitable as a carbon substrates for PHA synthesis. The WFOs obtained in the production of canned Baltic sprat and Baltic mackerel can be considered a promising and renewable substrate for PHA biosynthesis. Full article
(This article belongs to the Special Issue Advanced Degradable Biopolymers)
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16 pages, 2555 KiB  
Article
Biosynthesis of Bacterial Nanocellulose from Low-Cost Cellulosic Feedstocks: Effect of Microbial Producer
by Ekaterina A. Skiba, Nadezhda A. Shavyrkina, Maria A. Skiba, Galina F. Mironova and Vera V. Budaeva
Int. J. Mol. Sci. 2023, 24(18), 14401; https://doi.org/10.3390/ijms241814401 - 21 Sep 2023
Cited by 3 | Viewed by 1349
Abstract
Biodegradable bacterial nanocellulose (BNC) is a highly in-demand but expensive polymer, and the reduction of its production cost is an important task. The present study aimed to biosynthesize BNC on biologically high-quality hydrolyzate media prepared from miscanthus and oat hulls, and to explore [...] Read more.
Biodegradable bacterial nanocellulose (BNC) is a highly in-demand but expensive polymer, and the reduction of its production cost is an important task. The present study aimed to biosynthesize BNC on biologically high-quality hydrolyzate media prepared from miscanthus and oat hulls, and to explore the properties of the resultant BNC depending on the microbial producer used. In this study, three microbial producers were utilized for the biosynthesis of BNC: individual strains Komagataeibacter xylinus B-12429 and Komagataeibacter xylinus B-12431, and symbiotic Medusomyces gisevii Sa-12. The use of symbiotic Medusomyces gisevii Sa-12 was found to have technological benefits: nutrient media require no mineral salts or growth factors, and pasteurization is sufficient for the nutrient medium instead of sterilization. The yield of BNCs produced by the symbiotic culture turned out to be 44–65% higher than that for the individual strains. The physicochemical properties of BNC, such as nanofibril width, degree of polymerization, elastic modulus, Iα allomorph content and crystallinity index, are most notably dependent on the microbial producer type rather than the nutrient medium composition. This is the first study in which we investigated the biosynthesis of BNC on hydrolyzate media prepared from miscanthus and oat hulls under the same conditions but using different microbial producers, and showed that it is advisable to use the symbiotic culture. The choice of a microbial producer is grounded on the yield, production process simplification and properties. The BNC production from technical raw materials would cover considerable demands of BNC for technical purposes without competing with food resources. Full article
(This article belongs to the Special Issue Advanced Degradable Biopolymers)
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21 pages, 4767 KiB  
Article
Biodegradable Polyhydroxyalkanoates with a Different Set of Valerate Monomers: Chemical Structure and Physicochemical Properties
by Tatiana G. Volova, Natalia O. Zhila, Evgeniy G. Kiselev, Aleksey G. Sukovatyi, Anna V. Lukyanenko and Ekaterina I. Shishatskaya
Int. J. Mol. Sci. 2023, 24(18), 14082; https://doi.org/10.3390/ijms241814082 - 14 Sep 2023
Cited by 1 | Viewed by 1127
Abstract
The properties, features of thermal behavior and crystallization of copolymers containing various types of valerate monomers were studied depending on the set and ratio of monomers. We synthesized and studied the properties of three-component copolymers containing unusual monomers 4-hydroxyvalerate (4HV) and 3-hydroxy-4-methylvalerate (3H4MV), [...] Read more.
The properties, features of thermal behavior and crystallization of copolymers containing various types of valerate monomers were studied depending on the set and ratio of monomers. We synthesized and studied the properties of three-component copolymers containing unusual monomers 4-hydroxyvalerate (4HV) and 3-hydroxy-4-methylvalerate (3H4MV), in addition to the usual 3-hydroxybutyrate (3HB) and 3-hydroxyvalerate (3HV) monomers. The results showed that P(3HB-co-3HV-co-4HV) and P(3HB-co-3HV-co-3H4MV) terpolymers tended to increase thermal stability, especially for methylated samples, including an increase in the gap between melting point (Tmelt) and thermal degradation temperature (Tdegr), an increase in the melting point and glass transition temperature, as well as a lower degree of crystallinity (40–46%) compared with P(3HB-co-3HV) (58–66%). The copolymer crystallization kinetics depended on the set and ratio of monomers. For terpolymers during exothermic crystallization, higher rates of spherulite formation (Gmax) were registered, reaching, depending on the ratio of monomers, 1.6–2.0 µm/min, which was several times higher than the Gmax index (0.52 µm/min) for the P(3HB-co-3HV) copolymer. The revealed differences in the thermal properties and crystallization kinetics of terpolymers indicate that they are promising polymers for processing into high quality products from melts. Full article
(This article belongs to the Special Issue Advanced Degradable Biopolymers)
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20 pages, 6608 KiB  
Article
Three-Dimensional Printing of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(3HB-co-3HV)] Biodegradable Scaffolds: Properties, In Vitro and In Vivo Evaluation
by Ekaterina I. Shishatskaya, Aleksey V. Demidenko, Aleksey G. Sukovatyi, Alexey E. Dudaev, Aleksey V. Mylnikov, Konstantin A. Kisterskij and Tatiana G. Volova
Int. J. Mol. Sci. 2023, 24(16), 12969; https://doi.org/10.3390/ijms241612969 - 19 Aug 2023
Cited by 1 | Viewed by 1602
Abstract
The results of constructing 3D scaffolds from degradable poly(3-hydrosbutyrpate-co-3-hydroxyvalerate) using FDM technology and studying the structure, mechanical properties, biocompatibility in vitro, and osteoplastic properties in vivo are presented. In the process of obtaining granules, filaments, and scaffolds from the initial polymer material, a [...] Read more.
The results of constructing 3D scaffolds from degradable poly(3-hydrosbutyrpate-co-3-hydroxyvalerate) using FDM technology and studying the structure, mechanical properties, biocompatibility in vitro, and osteoplastic properties in vivo are presented. In the process of obtaining granules, filaments, and scaffolds from the initial polymer material, a slight change in the crystallization and glass transition temperature and a noticeable decrease in molecular weight (by 40%) were registered. During the compression test, depending on the direction of load application (parallel or perpendicular to the layers of the scaffold), the 3D scaffolds had a Young’s modulus of 207.52 ± 19.12 and 241.34 ± 7.62 MPa and compressive stress tensile strength of 19.45 ± 2.10 and 22.43 ± 1.89 MPa, respectively. SEM, fluorescent staining with DAPI, and calorimetric MTT tests showed the high biological compatibility of scaffolds and active colonization by NIH 3T3 fibroblasts, which retained their metabolic activity for a long time (up to 10 days). The osteoplastic properties of the 3D scaffolds were studied in the segmental osteotomy test on a model defect in the diaphyseal zone of the femur in domestic Landrace pigs. X-ray and histological analysis confirmed the formation of fully mature bone tissue and complete restoration of the defect in 150 days of observation. The results allow us to conclude that the constructed resorbable 3D scaffolds are promising for bone grafting. Full article
(This article belongs to the Special Issue Advanced Degradable Biopolymers)
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Review

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26 pages, 1589 KiB  
Review
Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models
by Nataliya A. Kolotyeva, Frida N. Gilmiyarova, Anton S. Averchuk, Tatiana I. Baranich, Nataliya A. Rozanova, Maria V. Kukla, Pavel P. Tregub and Alla B. Salmina
Int. J. Mol. Sci. 2023, 24(19), 14709; https://doi.org/10.3390/ijms241914709 - 28 Sep 2023
Cited by 2 | Viewed by 1047
Abstract
The development of brain in vitro models requires the application of novel biocompatible materials and biopolymers as scaffolds for controllable and effective cell growth and functioning. The “ideal” brain in vitro model should demonstrate the principal features of brain plasticity like synaptic transmission [...] Read more.
The development of brain in vitro models requires the application of novel biocompatible materials and biopolymers as scaffolds for controllable and effective cell growth and functioning. The “ideal” brain in vitro model should demonstrate the principal features of brain plasticity like synaptic transmission and remodeling, neurogenesis and angiogenesis, and changes in the metabolism associated with the establishment of new intercellular connections. Therefore, the extracellular scaffolds that are helpful in the establishment and maintenance of local microenvironments supporting brain plasticity mechanisms are of critical importance. In this review, we will focus on some carbohydrate metabolites—lactate, pyruvate, oxaloacetate, malate—that greatly contribute to the regulation of cell-to-cell communications and metabolic plasticity of brain cells and on some resorbable biopolymers that may reproduce the local microenvironment enriched in particular cell metabolites. Full article
(This article belongs to the Special Issue Advanced Degradable Biopolymers)
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38 pages, 2729 KiB  
Review
Production of Bacterial Exopolysaccharides: Xanthan and Bacterial Cellulose
by Viktor V. Revin, Elena V. Liyaskina, Marina V. Parchaykina, Irina V. Kurgaeva, Kristina V. Efremova and Nikolai V. Novokuptsev
Int. J. Mol. Sci. 2023, 24(19), 14608; https://doi.org/10.3390/ijms241914608 - 27 Sep 2023
Cited by 2 | Viewed by 2856
Abstract
Recently, degradable biopolymers have become increasingly important as potential environmentally friendly biomaterials, providing a wide range of applications in various fields. Bacterial exopolysaccharides (EPSs) are biomacromolecules, which due to their unique properties have found applications in biomedicine, foodstuff, textiles, cosmetics, petroleum, pharmaceuticals, nanoelectronics, [...] Read more.
Recently, degradable biopolymers have become increasingly important as potential environmentally friendly biomaterials, providing a wide range of applications in various fields. Bacterial exopolysaccharides (EPSs) are biomacromolecules, which due to their unique properties have found applications in biomedicine, foodstuff, textiles, cosmetics, petroleum, pharmaceuticals, nanoelectronics, and environmental remediation. One of the important commercial polysaccharides produced on an industrial scale is xanthan. In recent years, the range of its application has expanded significantly. Bacterial cellulose (BC) is another unique EPS with a rapidly increasing range of applications. Due to the great prospects for their practical application, the development of their highly efficient production remains an important task. The present review summarizes the strategies for the cost-effective production of such important biomacromolecules as xanthan and BC and demonstrates for the first time common approaches to their efficient production and to obtaining new functional materials for a wide range of applications, including wound healing, drug delivery, tissue engineering, environmental remediation, nanoelectronics, and 3D bioprinting. In the end, we discuss present limitations of xanthan and BC production and the line of future research. Full article
(This article belongs to the Special Issue Advanced Degradable Biopolymers)
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