Molecular Toxicology of New Drugs: New Insights

Dear Colleagues,

The number of molecules with pharmacological activities is growing and involves both small organic molecules and macromolecules, e.g., therapeutic proteins. It also includes novel psychoactive substances such as synthetic cannabinoids, synthetic opioids, or cathinone, for which only few data are available regarding the pharmacotoxicological profiles. Regardless of whether these compounds are used for a recreational or therapeutic purposes, a complete toxicity assessment is needed, both at the systemic and the molecular levels, to better understand the effects of such compounds on human health.

This Special Issue is dedicated to the broad array of molecular mechanisms triggered by new drugs with a special focus on molecular biology in both in vitro and in vivo studies. The use of omics approaches, such as proteomics or metabolomics, will provide new insights into the cellular and organ-specific pathways following new drug administration. Studies on the pharmacokinetics and pharmacodynamics of new drugs will also be considered, as well as the investigation of their effect on endogenous metabolites. Studies combining recent analytical approaches, such as molecular network, and biological experiments to decipher the toxicity of new drugs and their related metabolites will be included in the scope of the special issue.

This Special Issue is supervised by Prof. Dr. Pascal Houzé, assisted by Dr Romain Magny.

Prof. Dr. Pascal Houzé
Guest Editor

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• drug toxicity
• analytical chemistry
• pharmacokinetics
• in vivo toxicology
• in vitro toxicology
• metabolomics
• molecular network
• biomarkers of toxicity