Role of Mitochondrial Genetics in Brain Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 3124
Special Issue Editor
Interests: medicine neuroscience biochemistry; genetics and molecular biology psychology pharmacology; toxicology and pharmaceutics nursing immunology and microbiology agricultural and biological sciences
Special Issue Information
Dear Colleagues,
Human mitochondrial DNA, a 16,569 kb circular molecule, encodes 37 genes necessary to synthesize 13 essential subunits of the oxidative phosphorylation system that generates most of the cell's energy requirements. Maintaining the balance between energy demand and expenditure is extremely important for the proper functioning of the brain, as the brain uses up to 20% of the body's total energy, while it accounts for only 2% of the body's weight. Mitochondrial function therefore plays a key role in brain function, and mitochondrial medicine may provide the impetus for personalized treatments for brain disorders whose biological basis remains unclear, and for which effective treatments are still lacking. Recent and previous studies have already linked mitochondrial genetics to neuropsychiatric and neurological diseases. In this Special Issue, we call for papers that shed light on the association between mitochondrial dysfunction and brain disorders, as well as the outcome of treatments targeting mitochondria. Of particular interest are papers that 1) identify mitochondrial biomarkers, especially genetic ones, associated with psychiatric and neurological phenotypes, and 2) identify the relationship between mitochondrial dysfunction and phenotypic characteristics of brain disorders.
Dr. Lourdes Martorell
Guest Editor
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Keywords
- mitochondria
- mitochondrial DNA
- brain
- aging
- psychiatry
- treatment
- nutraceuticals
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