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Nanotechnology in Bone and Cartilage Repair and Regeneration

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: closed (20 June 2024) | Viewed by 1537

Special Issue Editor


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Guest Editor
1. Department of Research, Taipei Medical University/Shuang-Ho Hospital, New Taipei City 23561, Taiwan
2. Department of Dentistry, Taipei Medical University/Shuang-Ho Hospital, New Taipei City 23561, Taiwan
Interests: bone and cartilage engineering; biomaterials; nanoprobes; stem cell; bioreactor; optical imaging
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Special Issue Information

Dear Colleagues,

The aim of this Special Issue, “Nanotechnology in Bone and Cartilage Repair and Regeneration”, is to develop all areas of nanotechnologies to restore, maintain, or improve the function of damaged bone tissue and cartilage.

Over the last decade, nanotechnologies and/or nanomaterials have been highlighted as exhibiting superior cytocompatible, mechanical, electrical, optical, catalytic, and magnetic properties compared to conventional materials. “Nanotechnology in Bone and Cartilage Repair and Regeneration” will publish original studies on, but not limited to, the following topics:

  • Hierarchical structures and molecular particle networks;
  • Self-assemblies and directed assemblies of molecules;
  • Nanoparticles and nanocrystals;
  • Nanostructured materials and nanocarbons (e.g., carbon dots, graphene, nanotubes, and fullerenes);
  • Soft matter (e.g., biomaterials, polymers, aerogels, foams, and granular matter);
  • Films, membranes, coatings, surfaces, and interfacial materials;
  • Nanoporous and mesoporous materials;
  • Inorganic–organic hybrids and nanocomposites;
  • Nanoceramics, metals, and alloys.

Papers considered for peer review must contain substantial advances supported by regenerative insights.

Prof. Dr. Wen-Fu Lai
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

15 pages, 3658 KiB  
Article
Human Osteoblasts’ Response to Biomaterials for Subchondral Bone Regeneration in Standard and Aggressive Environments
by Stefania Pagani, Manuela Salerno, Giuseppe Filardo, Janis Locs, Gerjo J.V.M. van Osch, Jana Vecstaudza, Laura Dolcini, Veronica Borsari, Milena Fini, Gianluca Giavaresi and Marta Columbaro
Int. J. Mol. Sci. 2023, 24(19), 14764; https://doi.org/10.3390/ijms241914764 - 29 Sep 2023
Cited by 1 | Viewed by 1248
Abstract
Osteochondral lesions, when not properly treated, may evolve into osteoarthritis (OA), especially in the elderly population, where altered joint function and quality are usual. To date, a collagen/collagen–magnesium–hydroxyapatite (Col/Col-Mg-HAp) scaffold (OC) has demonstrated good clinical results, although suboptimal subchondral bone regeneration still limits [...] Read more.
Osteochondral lesions, when not properly treated, may evolve into osteoarthritis (OA), especially in the elderly population, where altered joint function and quality are usual. To date, a collagen/collagen–magnesium–hydroxyapatite (Col/Col-Mg-HAp) scaffold (OC) has demonstrated good clinical results, although suboptimal subchondral bone regeneration still limits its efficacy. This study was aimed at evaluating the in vitro osteogenic potential of this scaffold, functionalized with two different strategies: the addition of Bone Morphogenetic Protein-2 (BMP-2) and the incorporation of strontium (Sr)-ion-enriched amorphous calcium phosphate (Sr-ACP) granules. Human osteoblasts were seeded on the functionalized scaffolds (OC+BMP-2 and OC+Sr-ACP, compared to OC) under stress conditions reproduced with the addition of H2O2 to the culture system, as well as in normal conditions, and evaluated in terms of morphology, metabolic activity, gene expression, and matrix synthesis. The OC+BMP-2 scaffold supported a better osteoblast morphology and stimulated scaffold colonization, cell activity, and extracellular matrix secretion, especially in the stressed culture environment but also in normal culture conditions, with increased expression of genes related to osteoblast differentiation. In conclusion, the incorporation of BMP-2 into the Col/Col-Mg-HAp scaffold also represents an improvement of the osteochondral scaffold in more challenging conditions, supporting further preclinical studies to optimize it for use in clinical practice. Full article
(This article belongs to the Special Issue Nanotechnology in Bone and Cartilage Repair and Regeneration)
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