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Anticancer Medicine and Cancer Immunotherapy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1268

Special Issue Editor


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Guest Editor
Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Interests: cancer

Special Issue Information

Dear Colleagues,

Anticancer medicine and cancer immunotherapy is a multifaceted topic focusing on the latest advancements and strategies in combating cancer. The scope of this topic encompasses the development and application of anticancer medicine, specifically designed to hinder the growth and spread of cancer cells. The scope includes chemotherapy agents, targeted therapies and hormonal treatments, each with distinct mechanisms of action and efficacy profiles. 

A significant part of the discussion revolves around cancer immunotherapy, an innovative treatment approach that harnesses the body's immune system to fight cancer. This segment would cover various types of immunotherapies, such as checkpoint inhibitors, CAR T-cell therapies and cancer vaccines, elucidating their roles in activating or enhancing the immune response against cancer cells.

The scope also entails an exploration of challenges and breakthroughs in these fields, including the issues of drug resistance, side effects and the development of personalized medicine strategies. The potential synergy between anticancer drugs and immunotherapy, aiming to enhance treatment effectiveness and patient outcomes, is a crucial aspect.

Furthermore, the topic would address the ongoing research and clinical trials that are paving the way for new treatments, alongside the ethical and economic considerations involved in the development and accessibility of these advanced therapies. The goal is to provide a comprehensive overview of the current landscape and future prospects of anticancer medicine and cancer immunotherapy, highlighting their pivotal roles in the evolving fight against cancer.

Prof. Dr. Chao-Liang Wu
Guest Editor

Manuscript Submission Information

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Keywords

  • anticancer
  • cancer immunotherapy
  • CAR T-cell therapies
  • targeted therapies

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Published Papers (1 paper)

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Research

13 pages, 2336 KiB  
Article
Stage-Specific Alteration and Prognostic Relationship of Serum Fumarate Hydratase Autoantibodies in Gastric Cancer
by Natsuko Sasajima, Makoto Sumazaki, Yoko Oshima, Masaaki Ito, Satoshi Yajima, Hirotaka Takizawa, Hao Wang, Shu-Yang Li, Bo-Shi Zhang, Yoichi Yoshida, Takaki Hiwasa and Hideaki Shimada
Int. J. Mol. Sci. 2024, 25(10), 5470; https://doi.org/10.3390/ijms25105470 - 17 May 2024
Viewed by 1089
Abstract
The relationship between energy production and cancer is attracting attention. This study aimed to investigate the clinicopathological significance of fumarate hydratase (FH), a tricarboxylic acid cycle enzyme, in gastric cancer using autoantibodies as biomarkers. The study analyzed 116 patients who underwent gastric cancer [...] Read more.
The relationship between energy production and cancer is attracting attention. This study aimed to investigate the clinicopathological significance of fumarate hydratase (FH), a tricarboxylic acid cycle enzyme, in gastric cancer using autoantibodies as biomarkers. The study analyzed 116 patients who underwent gastric cancer surgery and 96 healthy controls. Preoperative serum FH autoantibody (s-FH-Ab) titers were analyzed using an immunosorbent assay with an amplified luminescent proximity homogeneous assay. Receiver operating characteristic analysis was used to determine the cutoff s-FH-Ab titer. Clinicopathological factors and prognosis were compared between the high and low s-FH-Ab groups. The s-FH-Ab levels were significantly higher in the gastric cancer group than in the control group (p = 0.01). Levels were elevated even in patients with stage I gastric cancer compared with healthy controls (p = 0.02). A low s-FH-Ab level was significantly associated with distant metastasis (p = 0.01), peritoneal dissemination (p < 0.05), and poor overall survival (p < 0.01). Multivariate analysis revealed that low s-FH-Ab levels were an independent risk factor for poor prognosis (p < 0.01). Therefore, s-FH-Ab levels may be a useful biomarker for early diagnosis and the prediction of prognosis in patients with gastric cancer. Full article
(This article belongs to the Special Issue Anticancer Medicine and Cancer Immunotherapy)
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