ERAD and Ubiquitination 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 3007
Special Issue Editor
Interests: cross presentation; dendritic cell; the ubiquitin proteasome system; antigen presentation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Last year, we launched the Special Issue “ERAD and Ubiquitination”, in which we published two research articles and four reviews. There has since been a constant influx of exciting findings in the literature, indicating this area of research has become a hot topic. Therefore, we wish to renew this Special Issue for 2021. ERAD (endoplasmic reticulum-associated degradation) has been identified as a cellular pathway of the protein quality control system in the ER, in which proteins in the ER specifically recognized as being misfolded or unassembled undergo retrograde transport out of the ER lumen and into the cytosol, where they are ubiquitinated and then degraded by proteasomes. Ubiquitination in ERAD plays a central role in the degradation of ERAD substrates by proteasomes but also functions as a recognition signal for retro-translocation and adjustment signals between ERAD-related molecular machinery. Disorders of ERAD-related ubiquitination result from activation of the UPR (unfolded protein response), and recent investigations have revealed that the UPR plays substantial roles in tumor progression, immunity, development, and aging. In this Special Issue of IJMS, we will address the role of ubiquitination in ERAD. This Special Issue will highlight the expansion in our understanding of the numerous roles of ERAD-related ubiquitination in various processes ranging from cellular homeostasis to individual homeostasis and development.
Prof. Dr. Jun Imai
Guest Editor
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Keywords
ERAD;
ubiquitination;
CUE domain;
ubiquitin chain conformation
