Extracellular Vesicles and Metastatic Niche 3.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (1 July 2022) | Viewed by 11882
Special Issue Editor
Interests: extracellular vesicles; tumor microenvironment; angiogenesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is the continuation of our 2020 Special Issue “Extracellular Vesicles and Metastatic Niche 2.0” and 2019 Special Issue “Extracellular Vesicles and Metastatic Niche”.
Extracellular vesicles (EVs) are membrane-enclosed particles released by both normal and tumor cells that operate as heterogeneous multisignal messengers involved in cell-to cell communication.
In cancer, EVs mediate tumor–stroma interactions affecting, among other things, cell proliferation, angiogenesis, immune surveillance, and drug resistance, thus supporting cancer growth. The tumor-promoting activities of EVs are not restricted to the local tumor microenvironment but also include dissemination, since EVs can enter the blood circulation, reach distant organs and, once there, educate resident cells to generate favorable environmental conditions; this process is known as pre-metastatic niche formation.
This Special Issue, “Extracellular Vesicles and Metastatic Niche 3.0”, of the International Journal of Molecular Sciences will comprise a selection of research papers and reviews covering various aspects of biochemistry and molecular and cellular biology on the role of EVs in the metastatic niche. Contributions on cell signaling pathways involved, functional studies, molecular characterization, as well as their impact on possible clinical implications, will be welcome. Studies on the set-up of specific in vitro and in vivo models will also be considered.
Dr. Ilaria Giusti
Guest Editor
Manuscript Submission Information
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Keywords
- Extracellular vesicles
- Metastatic niche
- Cancer
- EMT
- Exosomes
- Metastasis
- Microvesicles
- Tumor dormancy
- Tumor microenvironment
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