Role and Dynamics of Extracellular Vesicles in Central Nervous System Diseases 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 2108
Special Issue Editor
Interests: synaptic transmission; plasticity; electrophysiology; movement disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This collection of manuscripts will encompass a range of topics with the common denominator of extracellular vesicles in the context of biomarkers, basic biology, and cell–cell communication, as well as therapeutics. EVs are found in a wide range of biofluids, including cerebrospinal fluid, plasma, serum, and urine. They reflect the cargo of the parental cells and can inform about the tumor status in a noninvasive, real-time fashion. The bioactive molecules carried within EVs have also been shown to modulate the behavior of recipient cells in many ways. Specifically, EVs can shuttle between neurons and glia cells, likely influencing synaptic activity, morphological plasticity, and neurovasculature. In the presence of injury, EVs have been suggested to play a role in neuroprotection, while in neurodegeneration, EVs have been implicated in the spread and clearance of toxic aggregates. Finally, several studies have proposed using EVs as a delivery tool for small molecule drugs, protein, and nucleic acid to the CNS. Characteristics of EVs such as biocompatibility, low immunogenicity, and low toxicity profiles, make them highly valuable for therapeutic purposes.
Dr. Annalisa Tassone
Guest Editor
Manuscript Submission Information
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Keywords
- extracellular vesicles
- exosomes
- microvesicles
- CNS
- synapsis
- neurons
- toxic aggregates
- biomarker
- liquid biopsy
- therapeutics
- synaptic transmission
- synaptic plasticity
- molecular pathway
- neuronal circuitry
