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Natural Products with Anti-inflammatory and Anticancer Activity

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 459

Special Issue Editor


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Guest Editor
Department of Human Immunology, Institute of Medical Sciences, Medical College of Rzeszów University, University of Rzeszow, 35-959 Rzeszów, Poland
Interests: Natural products; immunology; autoimmune diseases; tumour immunology; dendritic cells; lncRNA
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Special Issue Information

Dear Colleagues,

Several inflammatory diseases and neoplasms are becoming more common in aging populations throughout the world. The clinically used anti-inflammatory or anti-cancer drugs suffer from the disadvantage of side effects, high cost of treatment and in some cases restricted availability. Natural products play a significant role in human health in relation to the prevention of inflammatory conditions as well as malignant tumours. Natural products can also be used in supplementary treatment or be the source for the development of new therapeutical agents. The present Special Issue will focus on anti-inflammatory and anti-cancer natural products belonging to different chemicals and showing attempts to enumerate the possible leads for further drug development.

Prof. Dr. Jacek Tabarkiewicz
Guest Editor

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Keywords

  • natural products
  • medicinal plants
  • inflammation
  • cancer
  • malignant tumour
  • anti-inflammatory
  • anti-cancer

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Published Papers (1 paper)

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Research

30 pages, 5381 KiB  
Article
Potentilla tormentilla Extract Loaded Gel: Formulation, In Vivo and In Silico Evaluation of Anti-Inflammatory Properties
by Jovana Bradic, Anica Petrovic, Milos Nikolic, Nikola Nedeljkovic, Marijana Andjic, Jovan Baljak, Vladimir Jakovljevic, Aleksandar Kocovic, Vanja Tadic, Aleksandra Stojanovic and Igor Simanic
Int. J. Mol. Sci. 2024, 25(17), 9389; https://doi.org/10.3390/ijms25179389 - 29 Aug 2024
Viewed by 272
Abstract
The objective of the study was to develop a novel topical gel by mixing Potentilla tormentilla ethanolic extract, thermosensitive poloxamer 407, and carbomer 940 and evaluating its stability and rheological behavior. The irritation potential of the gel was evaluated in accordance with the [...] Read more.
The objective of the study was to develop a novel topical gel by mixing Potentilla tormentilla ethanolic extract, thermosensitive poloxamer 407, and carbomer 940 and evaluating its stability and rheological behavior. The irritation potential of the gel was evaluated in accordance with the Organization for Economic Cooperation and Development Guidelines 404. The potential anti-inflammatory effects of the developed gel were evaluated in vivo in rats using the carrageenan-induced paw edema test. Moreover, the in silico binding affinity for chlorogenic and ellagic acid, as dominant components in the extract, against cyclooxygenase (COX) 1 and 2 was also determined. Our findings suggest that the gel containing Potentilla tormentilla extract remained stable throughout the observation period, exhibited pseudoplastic behavior, and caused no irritation in rats, thus being considered safe for topical treatment. Additionally, the developed gel showed the capability to reduce rat paw edema, which highlights significant anti-inflammatory potential. In silico analysis revealed that chlorogenic and ellagic acid exhibited a reduced binding affinity against COX-1 but had a similar inhibitory effect on COX-2 as flurbiprofen, which was confirmed by molecular dynamics results. The study proposes the possible application of Potentilla tormentilla ethanolic extract gel for the alleviation of localized inflammatory diseases; however, future clinical evaluation is required. Full article
(This article belongs to the Special Issue Natural Products with Anti-inflammatory and Anticancer Activity)
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