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Editorial Board Members’ Collection Series: Autoimmune Diseases—2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 310

Special Issue Editors


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Guest Editor

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Guest Editor
Institute of Biotechnology, Faculty Environment and Natural Sciences, Brandenburg University of Technology Cottbus-Senftenberg, 01968 Senftenberg, Germany
Interests: molecular diagnostics; quality management; autoimmune diseases; personalized medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, dedicated to autoimmunity, attempts to present a comprehensive overview of autoimmune diseases (ADs) and how the immune system self-targets in different conditions according to a balance determined by the genetic predisposition of the host, its gender, epigenetic factors, environmental circumstances, and other co-factors. Moreover, current knowledge from human and animal models is welcome regarding the pathogenic mechanisms of autoimmune diseases, clinical aspects of specific autoimmune diseases, as well as insights regarding biomarkers and specific therapies.

Prof. Dr. Yves Renaudineau
Dr. Dirk Roggenbuck
Guest Editors

Manuscript Submission Information

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Keywords

  • autoimmunity
  • autoimmune diseases
  • immunotherapy
  • biomarkers
  • pathogenic mechanisms

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Related Special Issue

Published Papers (1 paper)

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Research

12 pages, 1582 KiB  
Article
Increased Cytokine Levels in Seronegative Myositis: Potential Th17 Immune Response Implications
by Andrea Aguilar-Vazquez, Efrain Chavarria-Avila, José Manuel Gutiérrez-Hernández, Guillermo Toriz-González, Mario Salazar-Paramo, Gabriel Medrano-Ramirez, Steven Vargas-Cañas, Oscar Pizano-Martinez, Cynthia-Alejandra Gomez-Rios, Christian Juarez-Gomez, José-David Medina-Preciado, Maribell Cabrera-López, Edgar-Federico Quirarte-Tovar, Ligia Magaña-García, Alejandra-Rubí García-Gallardo, Edy-David Rubio-Arellano and Monica Vazquez-Del Mercado
Int. J. Mol. Sci. 2024, 25(20), 11061; https://doi.org/10.3390/ijms252011061 (registering DOI) - 15 Oct 2024
Abstract
Th17 cells are known for producing IL-17 and their role in the pathogenesis of various autoimmune diseases, including myositis. Likewise, the participation of the IL-23/IL-17 pathway in autoimmunity has been confirmed. In this study, we aimed to evaluate the behavior of cytokines in [...] Read more.
Th17 cells are known for producing IL-17 and their role in the pathogenesis of various autoimmune diseases, including myositis. Likewise, the participation of the IL-23/IL-17 pathway in autoimmunity has been confirmed. In this study, we aimed to evaluate the behavior of cytokines in myositis, focusing on the autoantibodies profile and the myositis core set measures. Twenty-five myositis patients were enrolled in this cross-sectional study. An expert rheumatologist evaluated the myositis core set measures. Serum levels of cytokines and chemokines were quantified using the LEGENDplex Multi-Analyte Flow Assay Kit from BioLegend. The autoantibodies detection was carried out using the line-blot assay kit Euroline: Autoimmune Inflammatory Myopathies from EUROIMMUN. We found higher serum levels of IL-33, CXCL8, IL-6, IL-23, and IL-12p70 in seronegative patients. A multiple linear regression analysis revealed that MYOACT scores could be predicted by the increment of IL-23 and the decrement of CCL2, IL-10, and CXCL8 serum levels. These findings suggest that the immune response in seronegative myositis patients exhibits an IL-23-driven Th17 immune response. The relevance of this discovery lies in its potential therapeutic implications. Insights into the IL-23-driven Th17 immune response in seronegative patients highlight the potential for targeted therapies aimed at modulating Th17 activity. Full article
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