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Blood Cells in Human Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 1580

Special Issue Editor


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Guest Editor
1. Galilee Research Institute (MIGAL), Kiryat Shmona, Israel
2. Faculty of Sciences, Tel Hai Academic College, Upper Galilee, Israel
Interests: physiological; biophysical; red blood cells; RBCs; metabolic complications

Special Issue Information

Dear Colleagues,

Red blood cells (RBCs, or erythrocytes) are phenomenal cells whose functional responsibility is far from limited to oxygen delivery to the tissues of our body. The unique properties of the RBC membrane and cytoskeleton components, as well as the molecular interactions and regulation of hemoglobin and other cytosolic molecules, precisely determine their unique functionality in transporting respiratory gases and physiological regulations. It is evident that RBC physiological and biophysical features are drastically altered under numerous inherited and pathological conditions (e.g., congenital hemoglobinopathies, cardiovascular and metabolic abnormalities, infections) and aging (in vivo and during storage). These aspects are at the top of dynamic, interdisciplinary, and multifaceted RBC research. We are pleased to share that we have opened a Special Issue dedicated to novel studies of the biochemical, hemodynamic, and biophysical properties of RBCs. State-of-the-art novel findings about the interaction of erythrocytes with external factors and the implications of this exposure in health will be welcome. These issues can be discussed from an experimental, clinical, or numerical point of view.

Dr. Leonid Livshits
Guest Editor

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Keywords

  • red blood cell
  • RBC membrane
  • RBC biophysical properties
  • RBC rheology
  • RBC mechanical properties
  • RBC membrane vesiculation
  • RBC clearance
  • RBC in diabetes
  • hemoglobinopathies
  • RBC storage
 

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Published Papers (1 paper)

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Research

17 pages, 5434 KiB  
Article
An Evaluation of the Safety of Intravenous Injections of the Natural Extracellular Hemoglobin M101 in Dogs and Monkeys
by Elisabeth Leize-Zal, Leïla Demini, Benoît Barrou and Franck Zal
Int. J. Mol. Sci. 2025, 26(2), 842; https://doi.org/10.3390/ijms26020842 - 20 Jan 2025
Viewed by 951
Abstract
Hemoglobin-based oxygen carriers have been developed to compensate the needs of blood for transfusions. Most of them were based on intracellular hemoglobin extracted from bovine or human blood, but unfortunately, this type of hemoglobin did not pass through the last steps of clinical [...] Read more.
Hemoglobin-based oxygen carriers have been developed to compensate the needs of blood for transfusions. Most of them were based on intracellular hemoglobin extracted from bovine or human blood, but unfortunately, this type of hemoglobin did not pass through the last steps of clinical trials. In this context, HEMARINA discovered a natural extracellular hemoglobin, possessing several advantages avoiding intracellular hemoglobin-related side effects. Many preclinical studies assessed the safety of M101 used in intravenous (IV) injection in rodents. To explore the safety of IV injections of M101 in large mammals, six dogs received each a single injection of liquid M101 according to a dose escalation with a 48 h follow-up. Then, two monkeys received multiple IV injections of the same dose of M101 every hour for seven hours. This study showed that single and multiple IV injections in dogs and monkeys did not cause clinical or histological lesions, nor did they induce immunological reactions. This makes M101 the best candidate to date for human use in emergency situations requiring blood and, in several diseases, causing hypoxia problems. Full article
(This article belongs to the Special Issue Blood Cells in Human Health and Disease)
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