Advances in Primary Nephropathies: Pathogenesis, Inflammatory Response and Advanced Treatments
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 December 2024 | Viewed by 1104
Special Issue Editors
Interests: microscopic vasculitis; primary glomerular diseases; membranous nephropathy; IgA nephropathy; clinical nephrology; interstitial nephritis; immune checkpoint inhibitors; autoimmune diseases; renal transplantation; clinical immunosuppression; experimental models; alloreactivity, autoimmunity; lupus nephritis; renal models; gene therapy; cell therapy; transplantation; ischemia–reperfusion
2. Experimental Nephrology Laboratory, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), 08907 L’Hospitalet de Llobregat, Spain
Interests: microscopic vasculitis; primary glomerular diseases; membranous nephropathy; IgA nephropathy; clinical nephrology; interstitial nephritis; immune checkpoint inhibitors; autoimmune diseases
Special Issue Information
Dear Colleagues,
IgA and membranous nephropathies are the most prevalent primary glomerular diseases and constitute a frequent etiology of end-stage renal failure. Recent advances in our knowledge of the pathogenesis of both nephropathies have highlighted new variables that will allow us to better understand the complex mechanisms involved in their development and pathogenesis.
A myriad of new protein markers in membranous nephropathy have been described that warrant further research to understand the pathways and mechanisms of this disease. Moreover, the “four hit” hypothesis in IgA nephropathy, with a central role in galactose-deficient IgA1, needs a better description, and new essential research items must be established, to develop a clear understanding of this disease.
The pharmaceutic industry is making considerable efforts to better understand both of these diseases, investigating alternative complement pathways, as well as B-cell blocking with anti-CD20 or anti-APRIL antibodies. This topic constitutes a hot spot in clinical nephrology.
This Special Issue entitled “Advances in Primary Nephropathies: Pathogenesis, Inflammatory Response and Advanced Treatments” will include papers investigating the pathological mechanisms involved in primary nephropathies, as well as diagnostics using new biomarkers. Furthermore, it will present experimental in vitro and in vivo studies and clinical studies examining potential new approaches to attenuating kidney dysfunction.
This Special Issue welcomes original research and review papers, with potential topics including, but not limited to, the keywords below.
Prof. Dr. Joan Torras-Ambròs
Dr. Juliana Bordignon-Draibe
Guest Editors
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Keywords
- primary glomerular diseases
- membranous nephropathy
- IgA nephropathy
- glomerular inflammatory mechanisms
- aberrantly glycosylated IgA1
- galactose-deficient IgA1 (Gd-IgA1)
- alternative complement pathway
- C5
- factor B
- factor D
- APRIL
- BAFF
- phospholipase A2 receptor (PLA2R)
- thrombospondin type I domain-containing 7A (THSD7A)
- exostosins 1 and 2 (EXT1/2)
- neural epidermal growth factor-like 1 protein (NELL-1)
- semaphorin 3B (Sema3B)
- neural cell adhesion molecule 1 (NCAM1)
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