Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.1
4.9
Journals
IJMS
Special Issues
Polyunsaturated Fatty Acids and Chronic Diseases
ijms-logo
Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Polyunsaturated Fatty Acids and Chronic Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 3963

Special Issue Editor

Dr. Varinderpal S. Dhillon

E-Mail Website
Guest Editor
Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide 5000, Australia
Interests: chronic diseases, fatty acids; genome damage; nutrigenomics; telomere attrition; polyunsaturated fatty acids (PUFAs)

Special Issue Information

Dear Colleagues,

In the past few decades, many studies—particularly those on the metabolism of fatty acids (especially polyunsaturated fatty acids)—have pointed to a changed disease spectrum in the general population. Chronic diseases such as diabetes, obesity, cardiovascular diseases, cancer and autoimmune disorders are the leading causes of mortality, and to some extent are due to our changed dietary pattern. Omega-3 fatty acids are essential for normal growth and development, and their dietary intake may play a crucial role in the prevention of many chronic diseases. Great progress has taken place in our knowledge and understanding of the physiologic and molecular mechanisms of the various fatty acids, including the dietary ratio of n-6/n-3, in health and disease. However, the most important challenge for us is to identify the optimal dietary intake of PUFAs that can provide benefits in the prevention of chronic diseases in various ethnic groups. There is a great need to design and carry out clinical trials in different ethnic groups to better understand the role of PUFA metabolism and genetic susceptibility in order to prevent chronic diseases.  

The main aim of the compiling this Special Issue is to present up-to-date knowledge and evidence on PUFAs related to the prevention of chronic diseases in diverse populations. Therefore, for this Special Issue we solicit the submission of original research articles and reviews focusing on topics including but not limited to the dietary intake of PUFAs in early life and its effect on enhancing the immune system, as well as omega-3 PUFAs in preventing neurodegenerative disorders, cardiovascular diseases, obesity, diabetes etc.

Dr. Varinderpal S. Dhillon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polyunsaturated fatty acids
  • inflammation
  • chronic diseases
  • dietary fatty acids
  • prevention
  • metabolism

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

16 pages, 545 KiB  
Communication
Red Blood Cell Fatty Acid Profiles Are Significantly Altered in South Australian Mild Cognitive Impairment and Alzheimer’s Disease Cases Compared to Matched Controls
by Varinderpal S. Dhillon, Philip Thomas, Sau L. Lee, Permal Deo and Michael Fenech
Int. J. Mol. Sci. 2023, 24(18), 14164; https://doi.org/10.3390/ijms241814164 - 15 Sep 2023
Viewed by 1462
Abstract
Nutritional imbalances have been associated with a higher risk for cognitive impairment. This study determined the red blood cell (RBC) fatty acid profile of newly diagnosed mild cognitive impairment (MCI) and Alzheimer’s disease (AD) patients compared to age and gender-matched controls. There was [...] Read more.
Nutritional imbalances have been associated with a higher risk for cognitive impairment. This study determined the red blood cell (RBC) fatty acid profile of newly diagnosed mild cognitive impairment (MCI) and Alzheimer’s disease (AD) patients compared to age and gender-matched controls. There was a significant increase in palmitic acid (p < 0.00001) for both MCI and AD groups. Saturated fatty acids were significantly elevated in the MCI group, including stearic acid (p = 0.0001), arachidic acid (p = 0.003), behenic acid (p = 0.0002), tricosanoic acid (p = 0.007) and lignoceric acid (p = 0.001). n-6 polyunsaturated fatty acids (PUFAs) were significantly reduced in MCI, including linoleic acid (p = 0.001), γ-linolenic acid (p = 0.03), eicosatrienoic acid (p = 0.009) and arachidonic acid (p < 0.00004). The n-3 PUFAs, α-linolenic acid and docosahexaenoic acid, were both significantly reduced in MCI and AD (p = 0.0005 and p = 0.00003). A positive correlation was evident between the Mini-Mental State Examination score and nervonic acid in MCI (r = 0.54, p = 0.01) and a negative correlation with γ-linolenic acid in AD (r = −0.43, p = 0.05). Differences in fatty acid profiles may prove useful as potential biomarkers reflecting increased risk for dementia. Full article
(This article belongs to the Special Issue Polyunsaturated Fatty Acids and Chronic Diseases)
►▼ Show Figures

Figure 1

13 pages, 2284 KiB  
Article
Fatty-Acid-Based Membrane Lipidome Profile of Peanut Allergy Patients: An Exploratory Study of a Lifelong Health Condition
by Elisabetta Del Duca, Anna Sansone, Mayla Sgrulletti, Federica Di Nolfo, Loredana Chini, Carla Ferreri and Viviana Moschese
Int. J. Mol. Sci. 2023, 24(1), 120; https://doi.org/10.3390/ijms24010120 - 21 Dec 2022
Cited by 1 | Viewed by 2123
Abstract
Peanut allergy is a lifelong, increasingly prevalent, and potentially life-threatening disease burdening families and communities. Dietary, particularly polyunsaturated fatty acids (PUFAs), intakes can exert positive effects on immune and inflammatory responses, and the red blood cell (RBC) membrane lipidome contains stabilized metabolic and [...] Read more.
Peanut allergy is a lifelong, increasingly prevalent, and potentially life-threatening disease burdening families and communities. Dietary, particularly polyunsaturated fatty acids (PUFAs), intakes can exert positive effects on immune and inflammatory responses, and the red blood cell (RBC) membrane lipidome contains stabilized metabolic and nutritional information connected with such responses. The fatty-acid-based membrane lipidome profile has been exploratorily evaluated in a small cohort of patients (eight males and one female, age range 4.1–21.7 years old, body mass index BMI < 25) with angioedema and/or anaphylaxis after peanut ingestion. This analysis was performed according to an ISO 17025 certified robotic protocol, isolating mature RBCs, extracting membrane lipids, and transforming them to fatty acid methyl esters for gas chromatography recognition and quantification. Comparison with a group of age- and BMI-matched healthy individuals and with benchmark interval values of a healthy population evidenced significant differences, such as higher levels of ω-6 (arachidonic acid), lower values of ω-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), together with an increased ω-6/ω-3 ratio in allergic patients. A significant inverse correlation was also found between specific immunoglobulin E (IgE) levels and ω-6 di-homo-gamma-linolenic acid (DGLA) and total PUFAs. Results of this preliminary study encourage screenings in larger cohorts, also in view of precision nutrition and nutraceuticals strategies, and stimulate interest to expand basic and applied research for unveiling molecular mechanisms that are still missing and individuating treatments in chronic allergic disorders. Full article
(This article belongs to the Special Issue Polyunsaturated Fatty Acids and Chronic Diseases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop