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Bioluminescent: Fluorescent Biomolecules and Nanomaterials
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Bioluminescent: Fluorescent Biomolecules and Nanomaterials

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (1 October 2022) | Viewed by 6107

Special Issue Editors

Prof. Dr. Fengshou Wu

E-Mail Website
Guest Editor
School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, China
Interests: bioimaging; carbon dots; fluorescence; porphyrin; photodynamic therapy; theranostics; nanomedicine; biosensing
Prof. Dr. Kai Wang

E-Mail Website
Guest Editor
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, College of Chemistry and Chemical Engineering, Hubei University, Wuhan, China
Interests: photodynamic therapy; luminescence; porphyrin; bioimaging; biosensing

Special Issue Information

Dear Colleagues,

The field of fluorescent biomolecules and nanomaterials, from fundamental studies to translational medicine, has received increasing attention in recent years owing to its diverse and promising applications. In fact, this cross-disciplinary research area has stimulated extensive studies and deep collaboration of scientists in different fields. To highlight recent novel developments in research on bioluminescent materials, the International Journal of Molecular Sciences is planning a Special Collection, where we as Guest Editors hope to gather the latest and most exciting results.

The International Journal of Molecular Sciences (ISSN 1422-0067; CODEN: IJMCFK; ISSN 1661-6596 for printed edition) provides an advanced forum for molecular studies in biology and chemistry, with a strong emphasis on molecular biology and molecular medicine. Our aim is to provide a rigorous peer review and enable rapid publication of cutting-edge research to educate and inspire the scientific community worldwide. The proposed submission deadline for this Special Issue is 1 October 2022. If you would like to contribute a paper but need more time, then please let us know, as we are happy to be flexible. All submitted manuscripts will undergo our standard thorough review process. Articles accepted in this Special Issue will be published in regular issues of the journal as soon as possible and grouped simultaneously into the Special Issue.

Prof. Dr. Fengshou Wu
Prof. Dr. Kai Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioimaging
  • biosensing
  • luminescent materials
  • carbon dots
  • nanomedicines
  • photodynamic therapy
  • photothermal therapy
  • theranostics

Published Papers (3 papers)

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Research

14 pages, 5900 KiB  
Article
Self-Assembled BODIPY Derivative with A-D-A Structure as Organic Nanoparticles for Photodynamic/Photothermal Cancer Therapy
by Guojing Li, Mengqian Yang, Qilong Sha, Li Li, Xiaogang Luo and Fengshou Wu
Int. J. Mol. Sci. 2022, 23(22), 14473; https://doi.org/10.3390/ijms232214473 - 21 Nov 2022
Cited by 2 | Viewed by 1599
Abstract
Organic nanomaterials have attracted considerable attention in the area of photodynamic and photothermal therapy, owing to their outstanding biocompatibility, potential biodegradability, well-defined chemical structure, and easy functionalization. However, it is still a challenge to develop a single organic molecule that obtains both photothermal [...] Read more.
Organic nanomaterials have attracted considerable attention in the area of photodynamic and photothermal therapy, owing to their outstanding biocompatibility, potential biodegradability, well-defined chemical structure, and easy functionalization. However, it is still a challenge to develop a single organic molecule that obtains both photothermal and photodynamic effects. In this contribution, we synthesized a new boron-dipyrromethene (BODIPY)-based derivative (DPBDP) with an acceptor–donor–acceptor (A-D-A) structure by coupling 3,6-di(2-thienyl)-2,5-dihydropyrrolo [3,4-c] pyrrole-1,4-dione (DPP) and BODIPY. To enhance the hydrophilicity of the BODIPY derivative, the polyethylene glycol (PEG) chains were introduced to the meso- position of BODIPY core. The amphiphilic DPBDP was then self-assembled into related nanoparticles (DPBDP NPs) with improved hydrophilicity and enhanced absorbance in the NIR region. DPBDP NPs could simultaneously generate the singlet oxygen (1O2) and heat under the irradiation of a single laser (690 nm). The 1O2 quantum yield and photothermal conversion efficiency (PCE) of DPBDP NPs were calculated to be 14.2% and 26.1%, respectively. The biocompatibility and phototherapeutic effect of DPBDP NPs were evaluated through cell counting kit-8 (CCK-8) assay. Under irradiation of 690 nm laser (1.0 W/cm2), the half maximal inhibitory concentration (IC50) of DPBDP NPs was calculated to be 16.47 µg/mL. Thus, the as-prepared DPBDP NPs could be acted as excellent candidates for synergistic photodynamic/photothermal therapy. Full article
(This article belongs to the Special Issue Bioluminescent: Fluorescent Biomolecules and Nanomaterials)
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12 pages, 3560 KiB  
Article
Red-Emissive Sulfur-Doped Carbon Dots for Selective and Sensitive Detection of Mercury (II) Ion and Glutathione
by Jinjin Zeng, Linhong Liao, Xiao Lin, Genyan Liu, Xiaogang Luo, Ming Luo and Fengshou Wu
Int. J. Mol. Sci. 2022, 23(16), 9213; https://doi.org/10.3390/ijms23169213 - 17 Aug 2022
Cited by 12 | Viewed by 2306
Abstract
Carbon dots (CDs) show great potential in bioimaging and biosensing because of their good biocompatibility and excellent optical properties. However, CDs with intense red emissions for sensitive and selective detection are rarely reported. Herein, we prepared the red-emissive carbon dots (RCDs) through a [...] Read more.
Carbon dots (CDs) show great potential in bioimaging and biosensing because of their good biocompatibility and excellent optical properties. However, CDs with intense red emissions for sensitive and selective detection are rarely reported. Herein, we prepared the red-emissive carbon dots (RCDs) through a facile hydrothermal method using tetra (4-carboxyphenyl) porphyrin (TCPP) and thiourea as starting materials. The obtained RCDs were characterized by TEM, XRD, and XPS. RCDs exhibited high water solubility and strong red emission (λem = 650 nm), with the fluorescence quantum yield as high as 26.7%, which was greatly higher than that of TCPP. Moreover, the as-prepared RCDs could be acted as a highly selective and sensitive probe for the detection of Hg2+ and glutathione (GSH) through the fluorometric titration method. The detection limits of Hg2+ and GSH were calculated to be 1.73 and 1.6 nM, respectively. The cellular experiments demonstrated the good biocompatibility of RCDs and their feasibility in bioimaging. Thus, this work provided a simple strategy to design and synthesize the highly red-emissive carbon dots, which showed promising application in biological and environmental assays. Full article
(This article belongs to the Special Issue Bioluminescent: Fluorescent Biomolecules and Nanomaterials)
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15 pages, 3209 KiB  
Article
Discovery of the Anticancer Activity for Lung and Gastric Cancer of a Brominated Coelenteramine Analog
by Patricia González-Berdullas, Renato B. Pereira, Cláudia Teixeira, José Pedro Silva, Carla M. Magalhães, José E. Rodríguez-Borges, David M. Pereira, Joaquim C. G. Esteves da Silva and Luís Pinto da Silva
Int. J. Mol. Sci. 2022, 23(15), 8271; https://doi.org/10.3390/ijms23158271 - 27 Jul 2022
Cited by 10 | Viewed by 1595
Abstract
Cancer is still a challenging disease to treat, both in terms of harmful side effects and therapeutic efficiency of the available treatments. Herein, to develop new therapeutic molecules, we have investigated the anticancer activity of halogenated derivatives of different components of the bioluminescent [...] Read more.
Cancer is still a challenging disease to treat, both in terms of harmful side effects and therapeutic efficiency of the available treatments. Herein, to develop new therapeutic molecules, we have investigated the anticancer activity of halogenated derivatives of different components of the bioluminescent system of marine Coelenterazine: Coelenterazine (Clz) itself, Coelenteramide (Clmd), and Coelenteramine (Clm). We have found that Clz derivatives possess variable anticancer activity toward gastric and lung cancer. Interestingly, we also found that both brominated Clmd (Br-Clmd) and Clm (Br-Clm) were the most potent anticancer compounds toward these cell lines, with this being the first report of the anticancer potential of these types of molecules. Interestingly, Br-Clm possessed some safety profile towards noncancer cells. Further evaluation revealed that the latter compound induced cell death via apoptosis, with evidence for crosstalk between intrinsic and extrinsic pathways. Finally, a thorough exploration of the chemical space of the studied Br-Clm helped identify the structural features responsible for its observed anticancer activity. In conclusion, a new type of compounds with anticancer activity toward gastric and lung cancer was reported and characterized, which showed interesting properties to be considered as a starting point for future optimizations towards obtaining suitable chemotherapeutic agents. Full article
(This article belongs to the Special Issue Bioluminescent: Fluorescent Biomolecules and Nanomaterials)
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