Molecular Basis and Advances of Targeted Therapy for Breast Cancer: Second Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 March 2025 | Viewed by 5
Special Issue Editors
Interests: cancer; resistance to TK or CDK inhibitors; epigenetics; NGSseq
Special Issues, Collections and Topics in MDPI journals
Interests: high mobility group A (HMGA) proteins; chromatin; regulation of gene expression; protein–protein interactions; post-translational modifications (PTMs); epithelial–mesenchymal transition; proteomics; tumor microenvironment; breast cancer; metastasis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue focuses on translational science in the hopes of shedding light on research focused on “Molecular Basis and Advances of Targeted Therapy for Breast Cancer” and the therapy on breast cancer and overcoming breast cancer therapy resistance. Breast cancer (BC) is the most frequent cancer and the second cause of death by cancer in women worldwide.
The BC molecular subtype can determine the personalized therapeutic approach, e.g., targeted treatments such as endocrine therapy for HR+ BC or anti-HER2 therapy for HER2+ BC. The major challenge in BC treatment is finding active therapies to treat triple-negative breast cancer (TNBC) patients since conventional targeted therapies cannot be administered for this specific BC subtype, which has the worst survival outcomes. the mechanisms underlying drug resistance are a good strategy to develop novel treatments for BC. Acquired drug resistance is one of the main restrictions to the efficacious treatment of cancer. The mTOR/PI3K/Akt pathway is involved in the mechanism of resistance in all BC molecular subtypes, but many data show that resistance results from drug exclusion, drug metabolism, and modification of the drug target due to mutation or overexpression. Depending on the therapy, one or more genetic or epigenetic modulations are required to confer resistance to treatment. The editors welcome submissions from researchers involved in basic cancer research as well as clinical research. The articles should demonstrate a clear understanding of tumor cells and treatment strategies specific to the tumor types and clarify the ways that lead to therapy resistance from cell lines to clinical trials. Reviews and original papers are both welcome.
Dr. Nicoletta Cordani
Prof. Dr. Manfioletti Guidalberto
Guest Editors
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Keywords
- breast cancer
- targeted therapy
- cancer therapy
- resistance
- epigenetic modulations
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