Molecular Mechanisms of Cell Death in Epithelial Cells: The Role of p53 Family
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 3575
Special Issue Editor
Interests: p53; cancers; tumor suppression; chemotherapy; transcriptomics; genomics; p53 gene family; transcriptional regulation; next-generation sequencing
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
P53 represents a key transcriptional factor involved in cellular response to genotoxic stresses. Cell death is the main p53-dependent cellular response to severe stress and irreparable DNA damage. All of the organism tissues and organs may suffer from stress coming from several sources, and epithelial tissue represents the first defense barrier to solar rays, hazardous substances and other potential dangerous sources of DNA damaging agents. In these terms, it is important to know the role of p53 (and of its related proteins family p63 and p73) in defending organisms from DNA-damaged dependent diseases onset, such as cancer. It is likewise important to know the consequences of a functional inactivation of the physiological activities of the proteins involved in cellular homeostasis and defense from genotoxic stresses, by analyzing the molecular alteration both in p53 family protein expression and in the downstream pathways involved in mechanisms such as cell cycle arrest, DNA repair, and cell death, above all. This Special Issue aims at collecting and shedding light on all the latest research and discoveries in this field, in order to give useful information for diagnostical knowledge as well as for pharmaceutical and therapeutical applications by the synthesis of molecular drugs.
Dr. Mariano Francesco Caratozzolo
Guest Editor
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Keywords
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P53
- tumor suppression
- apoptosis
- DNA damage
- genotoxic stress
- molecular network
- P53 gene family
- epithelial homeostasis
- P63 and p73
