Mechanisms of Protein–Ligand Interactions in Therapies for Lifestyle Diseases and Their Complications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 15 January 2025 | Viewed by 98
Special Issue Editor
Interests: glycation; serum albumin; protein-ligand interactions; binding properties; combination therapy; structural protein modifications; fatty acids; spectroscopy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
There can be no doubt that lifestyle diseases—“21st-century diseases”—significantly impact the quality of human life and lead to high social costs. These diseases are chronic and require specialized and regular treatment. In recent decades, there has been a concerning increase in the number of obese individuals exhibiting clinical features of metabolic syndrome. Obesity, particularly central obesity, is a significant factor in the development of insulin resistance, which leads to elevated blood glucose levels and, in the long term, the development of type 2 diabetes. Diabetes generates a range of serious complications, including cardiovascular diseases, nephropathy, retinopathy, and neuropathy, which consequently lead to a deterioration in quality of life, disability, and an increased risk of premature death.
Researching “Mechanisms of Protein–Ligand Interactions in Therapies for Lifestyle Diseases and Their Complications” is of great scientific importance. Due to numerous modifications, such as glycation and oxidation, the structural transformations of proteins, especially serum proteins, should be constantly monitored, particularly in chronic lifestyle diseases. The interaction of exogenous and endogenous ligands with transport proteins is a crucial factor influencing the course and efficacy of therapy.
The main goal of this Special Issue is to provide a platform for the publication of research on protein–ligand interactions, including proteins modified by various processes occurring in the body, using interdisciplinary techniques applied in laboratories, with particular emphasis on spectroscopic and calorimetric techniques.
Thank you for your time and consideration. I hope that you will consider participating in this Special Issue.
Dr. Agnieszka Szkudlarek
Guest Editor
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Keywords
- chronic diseases and their complications
- protein–ligand interactions
- protein modifications
- therapeutic efficacy
- binding affinity
- serum proteins
- pharmaceutical applications
- biomedical research
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