Advanced Spectroscopic and Calorimetric Techniques for Pharmaceutical Analysis
A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Pharmaceutical Processes".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 257
Special Issue Editor
Interests: glycation; serum albumin; protein-ligand interactions; binding properties; combination therapy; structural protein modifications; fatty acids; spectroscopy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The interactions between pharmaceutical compounds and proteins are foundational to biological sciences. The study of drug–protein interactions, particularly involving serum proteins, is among the most exciting areas in contemporary science, employing various spectroscopic and calorimetric techniques to analyze their structure–function relationships due to the complex physicochemical properties of the substances involved. Understanding these interactions is essential for developing a fundamental knowledge base related to molecular-level behaviours.
Advanced spectroscopic techniques offer detailed insights into the molecular structures and binding properties of pharmaceutical compounds. Techniques such as Nuclear Magnetic Resonance (NMR), Circular Dichroism (CD), and Ultraviolet–Visible (UV-Vis) and Fluorescence Spectroscopy (SFM) provide essential information on binding sites, conformational changes, and the dynamics of these processes. Understanding these aspects is vital for advancing drug design and ensuring the efficacy and safety of pharmaceutical products.
Calorimetric techniques provide valuable thermodynamic data on drug–protein interactions by measuring the heat changes associated with binding processes. Methods such as Isothermal Titration Calorimetry (ITC) and Differential Scanning Calorimetry (DSC) complement spectroscopic techniques by offering insights into the enthalpic and entropic contributions to these interactions. These data are crucial for optimizing drug efficacy and stability, helping us understand the energy changes which occur during drug–protein binding and contributing to the overall design and improvement of pharmaceutical compounds.
The Special Issue will include, but not be limited to, the following topics:
- Application of CD, UV-Vis, NMR, and Fluorescence Spectroscopy in studying drug–protein interactions;
- Thermodynamic analysis of drug binding using ITC and DSC;
- Structural and functional characterization of pharmaceutical compounds;
- Integration of spectroscopic and calorimetric data for a comprehensive analysis of ligand–protein interactions;
- Case studies demonstrating practical applications in drug discovery and development.
This Special Issue aims to provide a platform for publishing research on ligand–protein interactions using multidisciplinary techniques, particularly relevant for applications in the pharmaceutical and biomedical fields. I look forward to your valuable contributions to this exciting area of research.
Dr. Agnieszka Szkudlarek
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pharmaceutical applications
- ligand–protein interactions
- transport proteins
- protein modifications
- spectroscopic and calorimetric techniques
- protein structure and function
- drug efficacy and stability
- pharmaceutical compounds
- exogenous and endogenous ligands
- biomedical research
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