Oxidative Stress and Inflammation in the Tissue Repair—Pathways and Biotechnologies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 30 April 2025 | Viewed by 1546
Special Issue Editors
Interests: oxidative stress; inflammation process; tissue repair; skin diseases; inflammatory process; biotechnologies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxinflammation is an important process that is activated during the recovery of tissue lesions. Mitochondria play a fundamental role because, during the transport of the electrons in the inner mitochondria membrane, the production of free radicals, reactive oxygen species (ROS), and reactive nitrogen species (RNS), such as superoxide (O2•−), nitric oxide (NO•), nitrogen dioxide (NO2•), hydroxyl radical (OH•), hydroperoxyl radical (HO2•), and peroxyl (ROO•), is common. The relationship between oxidative stress and inflammation during tissue repair is linked to the activation of neutrophils, which are macrophages responsible for the release of interferon-γ (IFN-δ) and interleukins (IL) which will then promote the activation of NF-kB pathways and IL-12, TNF-α, IL-6, and IL-8 release. These are essential for resolving inflammatory progression. Currently, there is an increasing interest in the biotechnological and pharmacological development of more effective approaches to the treatment of different types of injuries in target organs. In regenerative medicine, natural products derived from plants, animals, minerals, and microorganisms have been considered rich sources of bioactive molecules, with potential relevance and applicability in direct or complementary strategies focused on tissue repair. This Special Issue aims to create an interdisciplinary platform involving morphological, physiological, biochemical, molecular, pathological, and biotechnological issues to discuss the identification, relevance, and applicability of natural products in the repair of tissue and organ injuries. We welcome primary research articles (in silico, in vitro, and in vivo) and secondary studies (critical integrative and systematic reviews) illustrating and stimulating the continuing effort to understand the effect of biotechnology compounds in the repair of the different morphological and/or functional disorders of target organs caused by physical, chemical, biological, and/or genetic processes.
Dr. Reggiani Vilela Goncalves
Dr. Rômulo Dias Novaes
Guest Editors
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Keywords
- oxidative stress
- inflammasome
- cytokines
- angiogenesis
- remodeling
- molecular pathways
- apoptotic alterations
- diabetes
- tissue repair
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