Circadian Biology in Human Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 November 2024 | Viewed by 738
Special Issue Editor
2. Diabetes Center, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland
Interests: circadian rhythms; metabolism; type 2 diabetes; molecular biology; RNA; lipids; liver
Special Issue Information
Dear Colleagues,
Photosensitive organisms from cyanobacteria to humans have evolved internal circadian timing systems, allowing them to anticipate environmental changes related to day/night variations. In mammals, this system is composed of a central pacemaker in the brain’s suprachiasmatic nucleus (SCN) and self-sustained and cell-autonomous oscillators present in almost all body cells. Accumulating evidence from rodent studies indicates that the temporal orchestration of the entire physiology is a major purpose of circadian clocks in central and peripheral tissues and leaves little doubt concerning the essential role of the circadian system in the coordination of body metabolism. Turning to studies in human subjects, a lot of recent work now supports the novel concept that a misalignment between the internal circadian clock and the external rhythm imposed by modern lifestyle can provoke alteration of multiple physiological processes. In this Special Issue, we aim to explore the genetic, molecular and biochemical mechanisms underlying the link between circadian clock disruption and the development of physiological dysfunctions.
Dr. Flore Sinturel
Guest Editor
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Keywords
- circadian rhythms
- metabolism
- misalignment
- synchronization
- molecular clock
- internal body clocks
- sleep–wake cycle
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