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Nano & Micro Materials in Healthcare 3.0
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Nano & Micro Materials in Healthcare 3.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1573

Special Issue Editor

Dr. M. Sheikh Mohamed

E-Mail Website
Guest Editor
Bio-Nano Electronics Research Centre, Toyo University, Kawagoe 350-8585, Japan
Interests: nanoscience; nanotechnology; biomaterials; nanomaterials; nano-drug delivery; cell scaffolding; tissue engineering; cancer therapy; plant nanotechnology; green chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue series “Nano & Micro Materials in Healthcare” and “Nano & Micro Materials in Healthcare 2.0”.

The Special Issue aims to provide an exciting multidisciplinary platform for research on the application of nano- and micromaterials in the field of therapeutics with the aim of improving human health. This Special Issue intends to cover a wide spectrum of multidisciplinary and interdisciplinary research areas related to biomedicine, targeted drug delivery, theranostics and personalized medicine. Pharmacological and toxicological evaluations of nano- and micromaterials are also welcome.

The scope of this Special Issue will cover (but is not limited to) the application of nano- and micromaterials in the following key subject areas:

  • Medicine—studies on basic, pre-clinical, translational and clinical research in drug delivery (nano/microDDS), imaging, photothermal and photodynamic therapy, theranostics, gene therapy and immunotherapy, as well as applications of nano- and micromaterials in various health-related issues, such as cancer and cardiovascular, metabolic and infectious diseases, to name a few, along with applications in vaccines and precision medicine;
  • Biomaterials—such as biocompatible/degradable materials, nano/microfibers, hydrogels, composites, 2D materials, biomimetic hybrids and biopolymers;
  • Tissue engineering and regenerative medicine—including scaffolds, grafts and patches, cell and tissue engineering, tissue regeneration and wound healing;
  • Devices for biomedical applications—such as BioMEMS, organs/lab-on-a-chip, diagnostic devices, biosensors, wearables, microfluidics, implantable devices and nano/microrobotics.

Dr. M. Sheikh Mohamed
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • theranostics
  • therapeutics
  • drug delivery
  • nanomedicine
  • precision medicine
  • regenerative medicine
  • diagnostics
  • toxicology
  • vaccines
  • cancer
  • cardiovascular disease
  • immunotherapy
  • gene therapy
  • infectious disease therapy
  • tissue engineering
  • imaging
  • implants
  • nano/microfluidics
  • targeting
  • translational medicine
  • biosensors

Published Papers (2 papers)

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Research

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24 pages, 7245 KiB  
Article
Theranostics Using MCM-41-Based Mesoporous Silica Nanoparticles: Integrating Magnetic Resonance Imaging and Novel Chemotherapy for Breast Cancer Treatment
by Indira C. B. Pires, Samia I. Shuchi, Braulio de V. A. Tostes, Dayane K. D. do N. Santos, William L. Burnett, Burke C. Leonce, Omar R. Harvey, Jeffery L. Coffer, Idio Alves de Sousa Filho, Petrônio Filgueiras de Athayde-Filho, Severino A. Junior and J. Michael Mathis
Int. J. Mol. Sci. 2024, 25(15), 8097; https://doi.org/10.3390/ijms25158097 - 25 Jul 2024
Viewed by 337
Abstract
Advanced breast cancer remains a significant oncological challenge, requiring new approaches to improve clinical outcomes. This study investigated an innovative theranostic agent using the MCM-41-NH2-DTPA-Gd3⁺-MIH nanomaterial, which combined MRI imaging for detection and a novel chemotherapy agent (MIH 2.4Bl) [...] Read more.
Advanced breast cancer remains a significant oncological challenge, requiring new approaches to improve clinical outcomes. This study investigated an innovative theranostic agent using the MCM-41-NH2-DTPA-Gd3⁺-MIH nanomaterial, which combined MRI imaging for detection and a novel chemotherapy agent (MIH 2.4Bl) for treatment. The nanomaterial was based on the mesoporous silica type, MCM-41, and was optimized for drug delivery via functionalization with amine groups and conjugation with DTPA and complexation with Gd3+. MRI sensitivity was enhanced by using gadolinium-based contrast agents, which are crucial in identifying early neoplastic lesions. MIH 2.4Bl, with its unique mesoionic structure, allows effective interactions with biomolecules that facilitate its intracellular antitumoral activity. Physicochemical characterization confirmed the nanomaterial synthesis and effective drug incorporation, with 15% of MIH 2.4Bl being adsorbed. Drug release assays indicated that approximately 50% was released within 8 h. MRI phantom studies demonstrated the superior imaging capability of the nanomaterial, with a relaxivity significantly higher than that of the commercial agent Magnevist. In vitro cellular cytotoxicity assays, the effectiveness of the nanomaterial in killing MDA-MB-231 breast cancer cells was demonstrated at an EC50 concentration of 12.6 mg/mL compared to an EC50 concentration of 68.9 mg/mL in normal human mammary epithelial cells (HMECs). In vivo, MRI evaluation in a 4T1 syngeneic mouse model confirmed its efficacy as a contrast agent. This study highlighted the theranostic capabilities of MCM-41-NH2-DTPA-Gd3⁺-MIH and its potential to enhance breast cancer management. Full article
(This article belongs to the Special Issue Nano & Micro Materials in Healthcare 3.0)
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Review

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33 pages, 2479 KiB  
Review
Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D
by Natallia V. Dubashynskaya, Valentina A. Petrova and Yury A. Skorik
Int. J. Mol. Sci. 2024, 25(10), 5359; https://doi.org/10.3390/ijms25105359 - 14 May 2024
Viewed by 1027
Abstract
Oromucosal drug delivery, both local and transmucosal (buccal), is an effective alternative to traditional oral and parenteral dosage forms because it increases drug bioavailability and reduces systemic drug toxicity. The oral mucosa has a good blood supply, which ensures that drug molecules enter [...] Read more.
Oromucosal drug delivery, both local and transmucosal (buccal), is an effective alternative to traditional oral and parenteral dosage forms because it increases drug bioavailability and reduces systemic drug toxicity. The oral mucosa has a good blood supply, which ensures that drug molecules enter the systemic circulation directly, avoiding drug metabolism during the first passage through the liver. At the same time, the mucosa has a number of barriers, including mucus, epithelium, enzymes, and immunocompetent cells, that are designed to prevent the entry of foreign substances into the body, which also complicates the absorption of drugs. The development of oromucosal drug delivery systems based on mucoadhesive biopolymers and their derivatives (especially thiolated and catecholated derivatives) is a promising strategy for the pharmaceutical development of safe and effective dosage forms. Solid, semi-solid and liquid pharmaceutical formulations based on biopolymers have several advantageous properties, such as prolonged residence time on the mucosa due to high mucoadhesion, unidirectional and modified drug release capabilities, and enhanced drug permeability. Biopolymers are non-toxic, biocompatible, biodegradable and may possess intrinsic bioactivity. A rational approach to the design of oromucosal delivery systems requires an understanding of both the anatomy/physiology of the oral mucosa and the physicochemical and biopharmaceutical properties of the drug molecule/biopolymer, as presented in this review. This review summarizes the advances in the pharmaceutical development of mucoadhesive oromucosal dosage forms (e.g., patches, buccal tablets, and hydrogel systems), including nanotechnology-based biopolymer nanoparticle delivery systems (e.g., solid lipid particles, liposomes, biopolymer polyelectrolyte particles, hybrid nanoparticles, etc.). Full article
(This article belongs to the Special Issue Nano & Micro Materials in Healthcare 3.0)
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