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Advances in Homeostasis and Metabolism in Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1596

Special Issue Editor


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Guest Editor
Department of Cellular and Molecular Physiology, Wu Tsai Institute for Mind and Brain, Yale Center for Molecular and Systems Metabolism, Yale University School of Medicine, New Haven, CT 06520, USA
Interests: cardiovascular diseases; nervous system diseases; nutritional and metabolic diseases; neurobiology of homeostasis; neurovascular plasticity; obesity; metabolic syndrome; thermoregulation

Special Issue Information

Dear Colleagues,

Homeostasis, the delicate balance that ensures an organism’s survival by regulating fundamental needs such as food, water, and warmth, profoundly influences behavior and physiology. An intricate network of complex and redundant circuits, both central and peripheral, orchestrates a complex “dance” to meet these survival instincts. Disruptions to those circuits can result in various disorders, affecting the proper functioning of cells, tissues, and organs. Our understanding of the neuronal, metabolic and cellular mechanisms orchestrating homeostasis is far from complete. Obtaining this knowledge will serve as the foundational step to preventing or treating health conditions arising from imbalances in these intricate systems (e.g., obesity).

In this Special Issue of the International Journal of Molecular Sciences, we eagerly invite researchers to submit both original research articles and review papers dedicated to advancing our understanding of the molecular underpinnings of homeostasis in health and unraveling how their disruption contributes to the onset of metabolic diseases.

Dr. Marc Schneeberger
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurobiology of homeostasis
  • peripheral organ metabolism
  • body-brain crosstalk
  • diabetes
  • metabolic syndrome

Published Papers (1 paper)

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Review

22 pages, 2712 KiB  
Review
Emerging Role of GCN1 in Disease and Homeostasis
by Yota Tatara, Shuya Kasai, Daichi Kokubu, Tadayuki Tsujita, Junsei Mimura and Ken Itoh
Int. J. Mol. Sci. 2024, 25(5), 2998; https://doi.org/10.3390/ijms25052998 - 5 Mar 2024
Viewed by 1287
Abstract
GCN1 is recognized as a factor that is essential for the activation of GCN2, which is a sensor of amino acid starvation. This function is evolutionarily conserved from yeast to higher eukaryotes. However, recent studies have revealed non-canonical functions of GCN1 that are [...] Read more.
GCN1 is recognized as a factor that is essential for the activation of GCN2, which is a sensor of amino acid starvation. This function is evolutionarily conserved from yeast to higher eukaryotes. However, recent studies have revealed non-canonical functions of GCN1 that are independent of GCN2, such as its participation in cell proliferation, apoptosis, and the immune response, beyond the borders of species. Although it is known that GCN1 and GCN2 interact with ribosomes to accomplish amino acid starvation sensing, recent studies have reported that GCN1 binds to disomes (i.e., ribosomes that collide each other), thereby regulating both the co-translational quality control and stress response. We propose that GCN1 regulates ribosome-mediated signaling by dynamically changing its partners among RWD domain-possessing proteins via unknown mechanisms. We recently demonstrated that GCN1 is essential for cell proliferation and whole-body energy regulation in mice. However, the manner in which ribosome-initiated signaling via GCN1 is related to various physiological functions warrants clarification. GCN1-mediated mechanisms and its interaction with other quality control and stress response signals should be important for proteostasis during aging and neurodegenerative diseases, and may be targeted for drug development. Full article
(This article belongs to the Special Issue Advances in Homeostasis and Metabolism in Health and Disease)
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