Human Mitochondrial Proteomics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 4634
Special Issue Editors
Interests: molecular disease mechanisms in inherited disorders; molecular chaperones; cellular and mitochondrial energy metabolisms; mitochondrial metabolic pathways; mitochondrial dysfunction in disease; neurological diseases; heart diseases
Special Issue Information
Dear Colleagues,
In recent years, there has been extensive development in the field of mitochondrial biology and in proteomics methodologies, which together, have driven the field of mitochondrial proteomics forward.
Mitochondria are multifaceted and regulate cellular bioenergetics, the degradation of fatty acids and amino acids, calcium levels, reactive oxygen species, and apoptosis. Because of their central function in many essential pathways, they are inherently involved in many different diseases. Defective mitochondria can be the primary causative factor, for example for inherited respiratory chain defects; however, they are also involved in cancer, diabetes, neurodegenerative disorders (Alzheimer’s, Parkinson’s, etc.), mental diseases (depression, schizophrenia), and cardiomyopathy.
Mitochondrial proteomics shed light on perturbation in mitochondrial functions and metabolic pathways, and are a powerful tool to delineate protein interactions, and for activity regulation by protein post-translational modifications, as well as for mitochondrial dynamics and stress responses.
For this Special Issue of IJMS on human mitochondrial proteomics, we invite scientists using and developing mitochondrial proteomics in the context of human biology and human diseases to contribute original and review articles.
Prof. Peter Bross
Prof. Johan Palmfeldt
Guest Editors
Manuscript Submission Information
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Keywords
- Mitochondrial dysfunction in human diseases
- Metabolic pathways
- Bioenergetics
- Mitochondrial dynamics
- Reactive oxygen species
- Redox-signaling
- Posttranslational protein modifications
- Protein quality control/proteostasis
- Mitochondria–ER interactions
- Mitophagy
- Apoptosis
- Respiratory chain supercomplexes
