Molecular and Cellular Mechanisms in Inflammatory Synaptopathy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 30517
Special Issue Editor
Interests: synaptic pathology; neurodegeneration; neuroinflammation; multiple sclerosis; experimental autoimmune encephalomyelitis inflammatory cytokines; microrna; excitotoxicity; synaptic plasticity; neuron-glia communication
Special Issue Information
Dear Colleagues,
In the past few years, three emerging concepts from different fields of neuroscience have significantly changed the current knowledge of the pathophysiology of neurological disorders: the concept of synaptic pathology or synaptopathy; the role of inflammation as a key factor influencing both the immature and mature brain; and the dysregulation of molecular mechanisms that drive synaptic transmission and plasticity. As technology has advanced, the ability to study the rich and complex diversity of each of these phenomena in detail has revealed their critical role in several brain pathologies. However, how these events are intermingled and cooperate in triggering or exacerbating neurological disorders is still not well understood.
This Special Issue is dedicated to research articles and reviews on molecular and cellular aspects that link CNS inflammation and synaptic dysfunction and loss in both human and non-human studies. The emphasis will be on neuroinflammatory processes that characterize various neurodegenerative diseases as well as on genetic, epigenetic, and environmental factors contributing to neurodevelopmental disorders.
Prof. Dr. Georgia Mandolesi
Guest Editor
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Keywords
- inflammation
- neurodegenerative disease
- synaptic dysfunction
- synaptic loss
- synaptic plasticity
- neurodevelopmental disorder
- cytokines
- microglia
- astroglia
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