Insights into the Molecular Regulation of Ion Transporters in Chronic Kidney Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (25 March 2023) | Viewed by 2972
Special Issue Editor
Interests: ion transporters; molecular and cell biology; membrane trafficking; ER stress; ER-associated degradation; renal physiology and physiopathology; tubulopathy, hypertension
Special Issue Information
Dear Colleagues,
The critical balance of fluid and electrolytes is strictly controlled by the kidney via numerous ion transporters expressed and localized in specific regions of the nephron. Genetic mutations or environmental factors can cause severe electrolyte imbalances in these ion transporters, leading to several clinical syndromes. Chronic renal disease may also alter the expression and function of membrane carriers and transporters in the kidney. Understanding the molecular and consequential effects of ion transporters’ aberrant trafficking and expression in health and disease is therefore essential for developing new treatment strategies for the prevention and treatment of chronic kidney disease (CKD). With this aim in mind, this Special Issue, “Insights into the Molecular Regulation of Ion Transporters in Chronic Kidney Disease”, will present original articles and reviews highlighting the state of the art of our current knowledge of the role of ion transport in CKD, the most recently proposed therapeutic strategies, and the insight gained from studies investigating these topics in both cell and animal models and patients.
Topics may include, but are not limited to:
- Regulation of the trafficking and phosphorylation of renal ion transporters;
- Role of endoplasmic reticulum-associated degradation of ion transporters in renal diseases;
- Defective ion transporters and kidney diseases;
- Targeted therapies to treat defective renal ion transporters;
- Cell and animal models for studying renal ion transporters in health and disease.
Dr. Kamel Laghmani
Guest Editor
Manuscript Submission Information
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Keywords
- kidney disease
- ion transporters
- membrane trafficking
- phosphorylation
- ER stress
- ER-associated degradation
- rescue
- animal models
- cell models
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