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Molecular Insights into Colitis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 1062

Special Issue Editors


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Guest Editor
Department of Physiology and Pharmacology “V. Erspamer”, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Interests: leaky gut; enteric glia; colitis; engineered probiotics
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Physiology and Pharmacology “V. Erspamer”, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Interests: enteric glia, colitis, gut-brain axis, neuroinflammation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, entitled "Molecular Insights into Colitis", delves into the molecular insights underlying colitis in attempt to offer a comprehensive insight into the pathological mechanisms driving this inflammatory bowel condition in both pre-clinical and clinical research. Submitted articles, reviews, and editorials employing advanced molecular techniques, describing key genetic, epigenetic, cellular, and protein-level alterations associated with colitis onset and progression, are welcome. High interest will be devoted to pharmacological studies describing dysregulation in crucial signaling pathways, cytokine profiles, and immune responses contributing to the inflammatory cascade during colitis. The present Special Issue explores potential therapeutic targets by elucidating molecular interactions and identifying candidate biomarkers for early diagnosis and intervention. Overall, this research provides a nuanced understanding of the molecular landscape of colitis, paving the way for targeted therapeutic approaches and personalized medicine strategies in the management of this complex inflammatory disorder.

Dr. Giuseppe Esposito
Dr. Luisa Seguella
Guest Editors

Manuscript Submission Information

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Keywords

  • colitis
  • treatments
  • molecular mechanisms of colon inflammation
  • preclinical and clinical studies

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Published Papers (1 paper)

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Review

19 pages, 1285 KiB  
Review
The Diagnosis of Intestinal Fibrosis in Crohn’s Disease—Present and Future
by Sara Jarmakiewicz-Czaja, Jolanta Gruszecka and Rafał Filip
Int. J. Mol. Sci. 2024, 25(13), 6935; https://doi.org/10.3390/ijms25136935 - 25 Jun 2024
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Abstract
Crohn’s disease (CD) progresses with periods of remission and exacerbations. During exacerbations, chronic inflammation leads to tissue destruction. As a result, intestinal fibrosis may develop in response to the ongoing inflammatory process. Fibrosis in CD should be considered the result of the response [...] Read more.
Crohn’s disease (CD) progresses with periods of remission and exacerbations. During exacerbations, chronic inflammation leads to tissue destruction. As a result, intestinal fibrosis may develop in response to the ongoing inflammatory process. Fibrosis in CD should be considered the result of the response of the intestinal wall (over) to the presence of inflammation in the deep structures of the intestinal wall. In the absence of ideal noninvasive methods, endoscopic evaluation in combination with biopsy, histopathological analysis, stool analysis, and blood analysis remains the gold standard for assessing both inflammation and fibrosis in CD. On the contrary, the ability to identify markers of intestinal fibrosis would help to develop new diagnostic and therapeutic methods to detect early stages of fibrosis. It is speculated that miRNAs may, in the future, become biomarkers for early noninvasive diagnosis in the treatment of intestinal fibrosis. The purpose of this review is to summarise existing diagnostic methods for Crohn’s disease and present recent scientific reports on molecular testing. Full article
(This article belongs to the Special Issue Molecular Insights into Colitis)
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