Glutamatergic Signaling in the Nervous System
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 February 2025 | Viewed by 225
Special Issue Editors
2. Department of Neuroscience, Mayo Clinic Graduate School of Biomedical Sciences, CRB, 03-031E, Scottsdale, AZ 85259, USA
Interests: brain imaging; substance use disorder; novel therapeutics; glutamatergic signaling; deep brain stimulation
Interests: retina; ribbon synapses; synaptic ribbon; active zone; synaptic signaling in photoreceptor ribbon synapses
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The discovery of glutamate as a major excitatory neurotransmitter has sparked interest in understanding its role in physiological brain processes and how glutamatergic alterations can lead to various neurological and psychiatric disorders. The brain’s glutamate concentration is tightly regulated at every step, from neuronal synthesis to storage into vesicles, release into synaptic space, binding to different glutamatergic receptors, downstream signaling, uptake to astrocytes, conversion to glutamine, and shuttling glutamine back from astrocytes to neurons to produce glutamate again and repeat the cycle. Glutamatergic signaling intersects with cellular energy economy and with other critical processes, such as the labile iron pool and potentially ferroptosis. Current glutamatergic medications, such as ceftriaxone, riluzole, memantine, ketamine, topiramate, lamotrigine, N-acetylcysteine, and D-cycloserine, show efficacy in treating various disorders. However, other nodes along the glutamatergic signaling pathway and the intersecting pathways could theoretically provide potential targets for pharmacotherapy. This Special Issue aims to delve into the exciting world of glutamate and its intersecting pathways.
Dr. Osama Abulseoud
Prof. Dr. Frank Schmitz
Guest Editors
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Keywords
- glutamate glutamine cycle
- neurotoxicty
- ferroptosis
- hyperglutamatergic states
- innovative pharmacological interventions
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