Molecular Insights into Transplantation and Machine Perfusion
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 March 2025 | Viewed by 96
Special Issue Editors
Interests: liver transplantation; inflammation; ischemia reperfusion injury
Special Issues, Collections and Topics in MDPI journals
Interests: liver transplantation; fatty liver; ubiquitin proteasome; liver; proteasome; liver diseases; transplantation; organ transplantation; organ donation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Organ transplantation is the most effective therapy to prevent patient death. While organ transplantation is a successful story, the inherent growing demand for transplantable organs poses a crucial challenge to solve in clinical transplantation. This shortage necessitates the taking advantage of suboptimal organs, such as those from donors after circulatory death (DCD), and steatosis. These organs are highly vulnerable to ischemia-reperfusion injury, which is inherent to organ retrieval, washout, and preservation before transplantation. The combination of preserving the organ quality and those damaging events can lead to primary graft dysfunction, delayed graft function, or late biliary complications; all of them are limiting factors for the graft’s viability and even to leading to transplant rejection.
Therefore, optimal preservation of the graft is essential for improving transplant outcomes. To achieve this, it is not only necessary to enhance cold preservation strategies but also to employ dynamic perfusion strategies with machine perfusion. This has been successfully implemented in clinical practice for the liver and kidney by using Hypothermic Oxygenated Perfusion (HOPE) and Normothermic Machine Perfusion (NMP), which help maintain graft integrity until transplantation. This new approach may significantly increase the pool of usable grafts, improve outcomes for recipients, and enhance the utilization of suboptimal organs.
In this Special Issue entitled “Molecular Insights into Transplantation and Machine Perfusion” we highlight research and novel therapeutic strategies aimed at achieving optimal graft preservation for transplantation, with a special focus on the liver, kidney, and other organs. This Special Issue will also include the development of new effluents/perfusates for optimizing the combination of cold static storage with HOPE and NMP ones in experimental and clinical settings. Metabolomic studies and graft pharmacological interventions are also welcome.
Prof. Dr. Joan Roselló-Catafau
Dr. Arnau Panisello-Roselló
Guest Editors
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Keywords
- transplantation (liver, kidney, and other organs)
- primary failure
- ischemia-reperfusion injury
- static graft preservation
- HOPE
- NMP
- cell signaling
- glycocalyx
- metabolomics
- mitochondria
- sterile inflammation
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