Cardiovascular Diseases: From Molecular Diagnosis to Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 January 2026 | Viewed by 13
Special Issue Editor
Interests: hemodynamic shear stress and the endothelium in the process of atherosclerosis; the role of hippo pathway in cardiovascular regulation; the endocrine function of endothelium in health and diseas; identification of new biomarker(s) for early diagnosis of atherosclerotic vascular disease; identification of new compounds for atherosclerosis prevention and treatment; inter-organ crosstalk and physical exercise
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Special Issue Information
Dear Colleagues,
Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide, demanding continuous innovation in how we diagnose, manage, and treat them. Recent years have witnessed a monumental shift from traditional, symptom-based approaches to a new era of precision cardiology, driven by profound advances in molecular biology, biotechnology, and computational science. This transformation enables earlier and more accurate diagnoses while paving the way for targeted, personalized therapies that were once thought to be science fiction.
This Special Issue, "Cardiovascular Diseases: From Molecular Diagnosis to Treatment," aims to capture the leading edge of this evolution. We seek to create a comprehensive collection of high-impact research that showcases the journey from a deep molecular understanding of disease mechanisms to the development and application of novel therapeutic interventions.
We welcome the submission of original research articles, comprehensive reviews, and short communications covering the full spectrum of recent advances in the cardiovascular field. Topics of interest include, but are not limited to the following:
Molecular Diagnosis and Risk Stratification
- Multi-omics Approaches: Use of genomics, transcriptomics, proteomics, and metabolomics for the discovery of novel biomarkers and the elucidation of disease pathways.
- Liquid Biopsies: Advances in circulating biomarkers, including cell-free DNA (cfDNA), microRNAs, and extracellular vesicles for non-invasive diagnosis and monitoring.
- Advanced Imaging: Integration of molecular imaging techniques (e.g., PET, SPECT) with anatomical imaging to visualize pathological processes at the cellular level.
- AI and Computational Biology: Application of machine learning and artificial intelligence for interpreting complex molecular data, predicting disease risk, and improving diagnostic accuracy.
Innovative Therapeutic Strategies
- Gene and Cell Therapies: Groundbreaking research in gene editing (e.g., CRISPR-Cas9), RNA therapeutics (siRNA, ASOs), and cell-based approaches (stem cells, CAR-T cells) for cardiac repair and regeneration.
- Nanomedicine: Development of novel nanomaterials and drug delivery systems for targeted treatment of atherosclerosis, myocardial infarction, and heart failure.
- Pharmacogenomics: Research on how genetic variations influence drug response, leading to personalized medication strategies for hypertension, hyperlipidemia, and antiplatelet therapy.
- Targeted Molecular Therapies: Discovery and development of drugs aimed at specific molecules and signaling pathways implicated in cardiovascular pathology.
We invite you to contribute your cutting-edge research to this Special Issue and help shape the future of cardiovascular medicine.
Dr. Li Wang
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cardiovascular diseases
- molecular diagnosis
- multi-omics approaches
- liquid biopsies
- molecular imaging
- gene and cell therapies
- nanomedicine
- pharmacogenomics
- targeted molecular therapies
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