MAPK in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 23078
Special Issue Editor
Interests: cellular signaling; MAPK; ERK; JNK; p38; cell differentiation; cell polarity; respiratory epithelium; neurodegeneration; apoptosis
Special Issue Information
Dear Colleagues,
MAPK (mitogen-activated protein kinase) signaling pathways regulate a variety of biological processes through very different mechanisms. In mammalians, seven subgroups have been identified, i.e., the four conventional MAPK subgroups extracellular-regulated kinase (ERK1/2), C-Jun N-terminal kinase (JNK), p38 MAPK, and ERK5, and three atypical MAPK subgroups, ERK3/4, ERK7/8, and nemo-like kinase (NLK). MAPKs play a pivotal role in converting extracellular stimuli into a wide range of cellular responses, including cell growth, migration, proliferation, differentiation, and apoptosis, among others.
In “MAPK in Health and Disease”, we welcome original research and review articles in the field, with a focus on but not limited to the molecular mechanics for MAPK activation, MAPK genomics and proteomics, new MAPK substrates, MAPK crosstalk, and the physiological role of MAPKs and MAPK-associated pathogenesis.
Sincerely,
Dr. Francisco Centeno
Guest Editor
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Keywords
- MAPK
- ERK
- p38
- JNK
- SAPK
- cell growth
- cell migration
- cell proliferation
- cell differentiation
- apoptosis
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