Molecular Players in Diagnostics and Therapeutics of Malignant Pleural Mesothelioma
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 31756
Special Issue Editors
2. Biotech Research & Innovation Center, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen N., Denmark
Interests: malignant pleural mesothelioma; molecular alterations; novel biomarkers; molecular subtypes; diagnosis; prognosticators and predictors
Interests: malignant pleural mesothelioma; molecular alterations; novel biomarkers; prognosticators and predictors; targeted therapy; immunotherapy
Special Issue Information
Dear Colleagues,
Malignant pleural mesothelioma (MPM) is a very aggressive cancer originating from the mesothelial cells lining the pleural cavity, usually associated with exposure to asbestos or asbestos-like fibers and characterized by challenging diagnostics, poor response to current standard therapies, and dismal prognosis. MPM is difficult to distinguish from reactive pleural conditions using conventional imaging- and histopathology-based methodologies. Moreover, MPM displays one of the lowest somatic mutation burdens among cancers and is mainly driven by inactivation of specific tumor suppressor genes, rather than activating oncogene-mutations. These features complicate the implementation of targeted and immunological therapies for this cancer.
However, recent seminal comprehensive studies have enlightened the role played in MPM by important genetic, epigenetic, and immunological alterations as well as by the interplay between genetic cancer susceptibility and environmental factors. This allows delineating novel molecular and clinical subtypes, as well as promising diagnostic and therapeutic strategies for MPM.
This Special Issue, “Molecular Players in Diagnostics and Therapeutics of Malignant Pleural Mesothelioma”, aims at collecting and welcomes original research articles, state-of-the-art review articles, and commentaries in this field.
Prof. Dr. Eric Santoni-Rugiu
Prof. Dr. Jens Benn Sørensen
Guest Editors
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Keywords
- Malignant pleural mesothelioma
- Molecular alterations
- Novel biomarkers
- Molecular subtypes
- Genetic cancer susceptibility
- Diagnosis
- Prognosticators and predictors
- Targeted therapy
- Immunotherapy
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