mTOR, Metabolism, and Diseases 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 6379
Special Issue Editor
Interests: cancer; metabolism; mRNA translation; mRNA degradation; mTOR
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mechanistic target of rapamycin (mTOR) integrates extracellular and intracellular signals (e.g., growth factors, insulin, nutrients, and oxygen) to stimulate anabolism, including protein, lipid, and nucleic acid synthesis, and bolster cellular growth and proliferation while suppressing autophagy. mTOR forms two distinct complexes, mTOR complex 1 (mTORC1) and 2 (mTORC2), which differ in their composition, downstream targets, regulation, and sensitivity to the naturally occurring allosteric mTOR inhibitor, rapamycin. Hyperactivation of mTOR frequently accompanies diseases characterized by perturbations in energy metabolism and cell growth, such as cancer and metabolic syndrome. The first generation of mTOR inhibitors, rapamycin and its analogs, have been used for the treatment of a few types of cancer with modest therapeutic effects. A new generation of ATP-competitive inhibitors that directly target the mTOR catalytic domain show potent and comprehensive inhibition and are in early clinical trials. Chronic rapamycin significantly increases lifespan in model organisms with better health indicators. The major clinical benefits of mTOR inhibition will likely be in the prevention or management of age-related diseases such as cancer, metabolic syndrome and its associated complications resulting in late life morbidity compression.
This special issue “mTOR, Metabolism, and Diseases” will cover a selection of recent research topics and current review articles in the field of the mTOR signaling pathway.
Dr. Masahiro Morita
Guest Editor
Manuscript Submission Information
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Keywords
- mTOR
- rapamycin
- inhibitor
- cancer
- metabolic syndrome
- aging
- mRNA translation
- 4E-BP
- S6K
- autophagy
