Targeting Mitochondria in Aging and Disease 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 20124
Special Issue Editors
Interests: mitochondria; metabolic diseases; oxidative stress; cardiovascular diseases; retinopathy; NAFLD; cancer; biomarkers; type 2 diabetes
Special Issues, Collections and Topics in MDPI journals
2. UO Laboratorio di Morfologia Umana Applicata, IRCCS San Donato, 20133 Milan, Italy
Interests: translational preclinical models of diseases; metabolic diseases; oxidative damage; endoplasmic reticulum stress; mitochondria; autophagy; mitophagy; role of antioxidants; ageing; sirtuins; natural compounds to limit metabolic diseases; cardiovascular damage and sirtuins modulation; obesity and mitochondrial endoplasmic reticulum interplay; selective autophagy in aging and disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Emerging evidence indicates that mitochondria, the essential energy powerhouse in cells, can be pharmacologically targeted. Aging dramatically impacts mitochondrial efficacy and plasticity, and to sustain mitochondrial biogenesis is the main objective of anti-aging medicine. Mitochondrial dysfunction at an ultrastructural level can be evidenced by the observation of abnormal cristae at the cellular level, characterized by altered size, number, and sub-cellular localization, as well as by reduced turnover and dynamics. These changes are associated with the disrupted function of the electron transport chain, showing lower electronic capacity, reduced membrane potential, increased production of superoxide, and reduced capacity to couple electronic flux to ATP synthesis. Neurons, skeletal and cardiac myocytes, and hepatocytes are among the most affected cell types due to their reliance on mitochondrial ATP output. Noted bioenergetic alterations—characteristics of aging— are also shared by cancer cells and have been suggested to have an impact on the control of cell death pathways, autophagy, and proteostasis. Recently, mitophagy has become a focus of attention in aging, metabolic diseases, and cancer. This is a selective mitochondrial clearing mechanism dependent on lysosomes, which has been shown to be defective or functionally altered, leading to the accumulation of dysfunctional mitochondria in the cell. Thus, targeting the mitochondria and restoring proper mitochondrial homeostasis are fundamental to treating disorders in which mitochondrial dysfunction has been shown to be a key driver of the disease. Novel developments have boosted our capacity to analyze mitochondria by evaluating cellular and circulating mtDNA—free and associated with regulatory factors. Therefore, the evaluation of epigenetic cues and mitochondrial medicine are challenging topics for future diagnostic and therapeutic developments. We believe that now is the time to support the exchange of ideas and the latest results on mitochondrial biology and medicine and have therefore decided to propose this Special Issue for interested clinical, academic, or industrial researchers all over the world. Original articles, comprehensive reviews, or perspective articles are welcome.
Topics of interest include, but are not limited to, the following:
- Mitochondria in aging;
- Mitochondria in exercise;
- Mitochondria in cancer,
- Mitochondria in neurodegeneration;
- Mitochondria in metabolic diseases;
- Mitochondrial mtDNA regulation;
- Mitochondrial oxidative pathways;
- Hypoxia regulation;
Antioxidants and nutraceutical drugs.
Dr. Maria Monsalve
Dr. Alessandra Stacchiotti
Guest Editors
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Keywords
- mitophagy
- new generation antioxidants
- exercise
- aging
- metabolic diseases
- neurodegenerative diseases
- mitochondrial plasticity
- targeting mitochondria
- epigenetics
- mtDNA
- cancer
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