Mitophagy in Neurodegeneration and Aging
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2333
Special Issue Editors
Interests: autophagy; mitophagy; neurodegeneration; cell death; aging
Interests: autophagy; mitophagy; neurodegeneration; repeat expansion diseases
2. Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), 28049 Madrid, Spain
3. Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), 10003 Cáceres, Spain
Interests: mitochondria; mitophagy; mlkl; necroptosis; rip; rotenone; mitochondrial; animal model
Special Issue Information
Dear Colleagues,
We are organizing a Special Issue of the International Journal of Molecular Sciences entitled “Mitophagy in Neurodegeneration and Aging”.
Mitochondria are organelles involved in crucial cellular processes, including the production of energy, lipid metabolism, or ion homeostasis. They also play key roles in the mechanisms of cell death and the generation of reactive oxygen species. Mitochondria are dynamic organelles that are continuously recycled through processes of biogenesis and degradation. Both processes must be balanced to maintain normal mitochondrial function.
Mitophagy is a type of selective autophagy that exclusively degrades damaged mitochondria or parts of them. Specifically, mitophagy is necessary to restore the mitochondrial steady state, regulating the mitochondrial population based on the metabolic demand or removing damaged mitochondria. Regarding this, failure of this mechanism can lead to neurodegeneration and aging. Strategies aimed at re-establishing these alterations could have beneficial effects. The goal of this Special Issue is, therefore, to highlight the role of mitophagy in chronic diseases such as neurodegenerative diseases and processes related to pathological aging. Here, we compile original manuscripts and review articles from outstanding experts in this field, covering the current state-of-the-art on the involvement of this catabolic process in the neurodegenerative and aging processes. Contributions that outline and review the key questions that still remain regarding the molecular mechanisms of mitophagy leading to the pathological course of these processes, as well as the translational applications of mitophagy-inducing compounds, are very welcome.
Dr. Rosa A. Gonzalez-Polo
Dr. Patricia Gomez-Suaga
Dr. Mireia Niso-Santano
Guest Editors
Manuscript Submission Information
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Keywords
- mitochondria
- neurodegeneration
- mitophagy
- aging
- cell death
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