New Chemotherapeutics, Alternative Methods & Old Challenges
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (15 November 2023) | Viewed by 4529
Special Issue Editors
Interests: oncology; cytoplasmic signaling pathways; anticancer molecules; toxicology
Special Issue Information
Dear Colleagues,
Chemotherapy, combined or not with surgery and radiotherapy, remains the most important and recommended treatment of the most cancers. However, several drawbacks, like drug resistance and adverse side effects, have limited the adherence and success, though bad outcomes have also stimulated the search for new effective and more secure anticancer drugs. On the other hand, this requires huge institutional efforts and use of a high number of experimental animals, mainly mammals, to achieve such medications, which are used in diagnostics as well as treatments. Alternatives to the animals in testing serving the same purposes that using whole animals do have been available. From the public health point of view, and despite massive investing in oncology research and development from public and private sources, the translation of advances into medicines that substantially enhance the treatment of many cancers remains frustratingly slow even using mammals. Therefore, some doubts might arise. Are alternative methods really adequate? What are the key challenges in anticancer drug development, and how should they be addressed? Less toxic and more effective treatment designs are often the main reasons for drug development. Further, drug development i) offers the opportunity to identify therapeutics medications for the treatment of rare diseases, including some types of cancers, which are generally ignored by R&D marketing programs of pharmaceutical companies; ii) save time and money; iii) improve productivity, and iv) reduce the risks, number of mammals used and human/material resources associated for the development of new drugs and the distance between drug discovery and commercial availability.
Supervised by Dr. Paulo Michel Pinheiro Ferreira and Dr. Gardenia Carmen Gadelha Militão and assisted by Dr. José Roberto de Oliveira Ferreira, this Special Issue invites researchers to contribute with original or review articles focused on techniques for discovering and development of antitumor molecules/formulations considering the traditional and alternative pharmacological, toxicokinetic and toxicogenetic in vitro and in vivo tools to predict bioactivity, toxicity and clinical efficacy to make the P&D of anticancer drugs faster in order to improve patients’ survival, quality of life and reduction of organ-specific side effects.
Dr. Paulo Michel Pinheiro Ferreira
Dr. Gardenia G.C. Militao
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- tumor chemoresistance
- angiogenesis inhibition
- solid tumors
- in vitro models
- failure predic-tion
- cytoplasmic signaling pathways
- lead antitumor molecules
- in vivo toxicity
- organ-specific side effects
