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Natural Products as Metabolic Modulators in the Tumor Microenvironment
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Natural Products as Metabolic Modulators in the Tumor Microenvironment

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (21 April 2023) | Viewed by 8338

Special Issue Editor

Dr. Jaemoo Chun

E-Mail Website
Guest Editor
Korean Medicine (KM) Convergence Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Korea
Interests: cancer metabolism; tumor microenvironment; immuno-oncology; therapeutic resistance; natural products; phytomedicine

Special Issue Information

Dear Colleagues,

Targeting signal transduction in cancer metabolism, including glucose, fatty acid, and amino acid metabolism, has emerged as a promising avenue in cancer therapeutics. It is important to understand how cancer cells reprogram their metabolism to proliferate and gain survival advantages in the complex tumor microenvironment, comprising a heterogeneous population of cancer cells, stromal cells, and infiltrating immune cells, together with extracellular matrix components. Hence, modulating cancer metabolism in the tumor microenvironment and their metabolic crosstalk with other cells could represent a potential anticancer therapeutic strategy. The use of natural products for this endeavor is especially promising, due to their diverse structures and ability to affect multiple targets. Bioactive compounds from natural products may reshape the metabolism of various cells in the tumor microenvironment, providing anti-tumor immunity. This Special Issue, “Natural Products as Metabolic Modulators in the Tumor Microenvironment”, welcomes original research and review articles addressing the latest advances and emerging trends in anticancer therapies using natural products. Topics include, but are not limited to: targeting cancer metabolism, signaling pathways in regulating cancer metabolism, immune metabolism in the tumor microenvironment, and modulating the tumor microenvironment.

Dr. Jaemoo Chun
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer metabolism
  • tumor microenvironment
  • cancer therapeutics
  • cancer immunity
  • metabolic target
  • immune metabolism
  • natural products
  • phytomedicines

Published Papers (1 paper)

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Review

33 pages, 3992 KiB  
Review
A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
by Partha Biswas, Dipta Dey, Polash Kumar Biswas, Tanjim Ishraq Rahaman, Shuvo Saha, Anwar Parvez, Dhrubo Ahmed Khan, Nusrat Jahan Lily, Konka Saha, Md Sohel, Mohammad Mehedi Hasan, Salauddin Al Azad, Shabana Bibi, Md. Nazmul Hasan, Mohammed Rahmatullah, Jaemoo Chun, Md. Ataur Rahman and Bonglee Kim
Int. J. Mol. Sci. 2022, 23(19), 11746; https://doi.org/10.3390/ijms231911746 - 4 Oct 2022
Cited by 55 | Viewed by 7779
Abstract
Reactive oxygen species (ROS) induce carcinogenesis by causing genetic mutations, activating oncogenes, and increasing oxidative stress, all of which affect cell proliferation, survival, and apoptosis. When compared to normal cells, cancer cells have higher levels of ROS, and they are responsible for the [...] Read more.
Reactive oxygen species (ROS) induce carcinogenesis by causing genetic mutations, activating oncogenes, and increasing oxidative stress, all of which affect cell proliferation, survival, and apoptosis. When compared to normal cells, cancer cells have higher levels of ROS, and they are responsible for the maintenance of the cancer phenotype; this unique feature in cancer cells may, therefore, be exploited for targeted therapy. Quercetin (QC), a plant-derived bioflavonoid, is known for its ROS scavenging properties and was recently discovered to have various antitumor properties in a variety of solid tumors. Adaptive stress responses may be induced by persistent ROS stress, allowing cancer cells to survive with high levels of ROS while maintaining cellular viability. However, large amounts of ROS make cancer cells extremely susceptible to quercetin, one of the most available dietary flavonoids. Because of the molecular and metabolic distinctions between malignant and normal cells, targeting ROS metabolism might help overcome medication resistance and achieve therapeutic selectivity while having little or no effect on normal cells. The powerful bioactivity and modulatory role of quercetin has prompted extensive research into the chemical, which has identified a number of pathways that potentially work together to prevent cancer, alongside, QC has a great number of evidences to use as a therapeutic agent in cancer stem cells. This current study has broadly demonstrated the function-mechanistic relationship of quercetin and how it regulates ROS generation to kill cancer and cancer stem cells. Here, we have revealed the regulation and production of ROS in normal cells and cancer cells with a certain signaling mechanism. We demonstrated the specific molecular mechanisms of quercetin including MAPK/ERK1/2, p53, JAK/STAT and TRAIL, AMPKα1/ASK1/p38, RAGE/PI3K/AKT/mTOR axis, HMGB1 and NF-κB, Nrf2-induced signaling pathways and certain cell cycle arrest in cancer cell death, and how they regulate the specific cancer signaling pathways as long-searched cancer therapeutics. Full article
(This article belongs to the Special Issue Natural Products as Metabolic Modulators in the Tumor Microenvironment)
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