The Microbiota–Gut–Brain Axis in Behaviour and Brain Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 28824
Special Issue Editors
Interests: neuropharmacology; neurodegeneration; neuroinflammation; glia; microbiota; neurodegenerative diseases; hippocampus; behaviour
Special Issues, Collections and Topics in MDPI journals
Interests: neuroinflammation; memory; aging; cholinergic system; Alzheimer’s disease; hippocampus
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The gut and its microbiota (MB-gut) is the largest absorption organ and reservoir of bacteria in the human body. The MB-gut is considered a single system whose interactions give rise to responses that affect the functions of the whole body. The central nervous system is in continuous cross-talk with the MB-gut in the so-called MB-gut–brain axis, and many bottom-to-top pathways, activated by MB products, are necessary for the correct development and physiological functions of the brain.
Dysbiosis contributes to many pathological conditions in both the aged and young population. Elucidating how the MB-gut can affect the central nervous system in aging, Alzheimer’s disease, multiple sclerosis and other neurodegenerative pathologies is of the utmost importance. Understanding the interactions between the MB-gut, the enteric system, immune cells, neurons and glia and their implications for host defense, tissue repair and neurodegeneration will be crucial to identifying new actors in the molecular basis of diseases.
In this regard, it is necessary to follow a multidisciplinary approach extended to all the districts and components of the complex MB-gut–brain axis. In particular, the analysis of the MB-gut-driven alterations in the neuron–astrocyte–microglia triad will highlight neurodegenerative mechanisms related to differential recruitment/activation of glial cells, will improve the knowledge of molecules involved in neurons/glia communication and elucidate MB-gut changes that could prevent and/or delay neurodegeneration.
In this regard, investigators are invited to contribute to this Special Issue with original research articles and review articles that can improve the understanding of the role of MB-gut–brain axis alteration in normal brain aging and neurodegenerative disease.
Dr. Daniele Lana
Prof. Dr. Maria Grazia Giovannini
Guest Editors
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Keywords
- gut microbiota
- Alzheimer’s disease
- multiple sclerosis
- neurodegenerative diseases
- neurodegeneration
- neuroinflammation
- glia-neuron interaction
- behaviour
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