Updates on Neuroendocrine Research in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (15 March 2023) | Viewed by 5365
Special Issue Editor
Special Issue Information
Dear Colleagues,
Neuroendocrinology emerged as a new science in the middle of the 20th century after the discovery that the brain itself can act as an endocrine organ due to its ability to produce hormones, called neurohormones. The neuroendocrine system plays a complex and multifaceted role in the maintenance of homeostasis. In this homeostatic function are involved many brain structures, including the hypothalamus, the anterior pituitary, and an end-organ or target tissues functioning together as an axis, regulated by short or long-loop feedback systems. The neuroendocrine system is made up of special cells called neuroendocrine cells, spread throughout the body, able to receive messages from the nervous system and respond by making and releasing hormones determining the physiologic responses to environmental stimuli. Traditionally, this field has relied on behavioral, hormonal and nervous changes as the “read-outs” elicited by the manipulations of endocrine signals.
In the recent years many of the neuroendocrine studies have been focused on the Diffused Neuroendocrine System (DNS), a heterogeneous group of specialized cells, of various embriologic origins, that works by the integration of different structures such as the endocrine pancreas, the anterior pituitary, the adrenals, acting as a regulatory organ. The anatomical, embriologic and functional differences among these cells can explain the heterogeneity of their pathologies. To this heterogeneity corresponds a variety of neuroendocrine tumors, and research on this field has markedly increased, with particular efforts to find early biomarkers of pathogenicity.
This Special Issue is focused on Neuroendocrine Research in Health and Disease, and it would include original articles on both physiological and pathological aspects related with alterations of the Neuroendocrine system.
Dr. Ilaria Ceccarelli
Guest Editor
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