Neuropathic Pain: Molecular Mechanism and Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (15 February 2023) | Viewed by 4633
Special Issue Editor
Interests: assessment and management of neuropacic pain; pharmacotherapy for managing neuropathic pain; basic research about mechanisms of neuropathic pain; excitatory transmission in the spinal dorsal horn; GABAergic inhibitory synaptic transmission in the spinal dorsal horn; expression of the GABA receptor subunits in the spinal dorsal horn; expression of NMDA receptors in serotonergic and/or GABAergic neurons in the midbrain periaqueductal gray
Special Issue Information
Dear Colleagues,
Analgesic opioids have been playing an important role in pain management for a long time. It has been pointed out that the use of analgesic opioids might be inadequate in countries like Japan, while North America suffers from overprescription of these medications. To promote the proper use of opioid analgesics and raise awareness, this Special Issue welcomes original research and review articles. We especially welcome reviews focusing on clarifying the mechanisms of neuropathic pain, the molecular biology of opioid receptor characteristics, acute tolerance to opioid analgesics, and hyperalgesia, which include, but are not limited to, differential expression of NMDA receptors in serotonergic and/or GABAergic neurons in the midbrain periaqueductal gray; changes in characteristics of NMDA receptors subunits in the spinal dorsal horn; functional and structural changes in GABA receptor subunits in the spinal dorsal horn; the relationship between HPC-1/syntaxin 1A and synaptic plasticity in the nociceptive pathway; and others in peripheral inflammation and peripheral nerve injury.
Prof. Dr. Shigeki Yamaguchi
Guest Editor
Manuscript Submission Information
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Keywords
- neuropathic pain
- nociceptive pathway
- serotonergic neuron
- NMDA receptor
- GABA receptor
- synaptic plasticity
- syntaxin 1A
- whole-cell recording
- ingle-cell RT-PCR
