Molecular Mechanisms and Treatments of Dependence and Neurotoxicity of Amphetamine-Type Stimulants
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 2916
Special Issue Editor
Interests: methamphetamine use disorder; methamphetamine neurotoxicity; the role of protein-ubiquitin ligase parkin in methamphetamine use disorder and neurotoxicity; neurodegeneration and neuroprotection
Special Issue Information
Dear Colleagues,
Amphetamine-type stimulants (ATSs) such as methamphetamine and 3,4-methylene-dioxymethamphetamine (MDMA, Ecstasy) are highly addictive drugs with neurotoxic properties. The use of ATSs is a global and growing phenomenon, and in recent years there has been a pronounced increase in the production and use of ATSs worldwide. Preclinical studies have demonstrated that, in addition to having the potential for abuse, ATS drugs have a potential to elicit neurotoxic effects, particularly at high doses. There are no FDA-approved pharmacotherapies to treat ATS dependence, and there are no appropriate therapeutic strategies to manage the neurological and neuropsychological problems associated with ATS abuse. This Special Issue will review current knowledge on molecular mechanisms underlying the dependence and neurotoxicity of methamphetamine, MDMA, and other ATSs, as well as developing strategies to treat ATS dependence and resultant neurotoxicity. The emphasis will be placed on methamphetamine, as its abuse in the United States has been increasing, together with the deaths from methamphetamine overdose. Consequently, the development of effective pharmacotherapy for methamphetamine dependence and the neurotoxic effects of this drug is a high priority.
Prof. Dr. Anna Moszczynska
Guest Editor
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Keywords
- Amphetamine-type stimulants
- Amphetamine-type stimulant dependence
- Amphetamine-type-stimulant neurotoxicity
- Amphetamine-type-stimulant-induced oxidative damage, degeneration, and inflammation
- Therapies for amphetamine-type-stimulant dependence
- Methamphetamine use disorder
- Methamphetamine toxicities
- Emerging drug targets for pharmacotherapies to treat amphetamine-type-stimulant dependence and neurotoxicity
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