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Molecular Pathogenesis and Therapies for Retinal and Optic Nerve Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 December 2025 | Viewed by 2057

Special Issue Editor


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Guest Editor
Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba 260-8670, Japan
Interests: diabetic retinopathy; neuronal cell death; neurovascular units; axonal degeneration; glial changes; vascular abnormalities; neuroprotection; regeneration; optic coherence tomography; visual function
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Special Issue Information

Dear Colleagues, 

Most retinal and optic nerve diseases, such as diabetic retinopathy, glaucoma, retinitis pigmentosa, optic neuritis, or optic neuropathy, are sight-threatening diseases that cause vision loss. Neurovascular abnormalities are involved in the pathogenesis of most retinal and optic nerve diseases, and neuronal cell death as well as axon degeneration are irreversible changes that lead directly to vision loss. The establishment of therapeutic approaches, including neuroprotection and regeneration in addition to neurovascular protection, are required to protect the visual function of patients with retinal and optic nerve diseases.

This Special Issue focuses on the pathogenesis of and therapeutic approaches for retinal and optic nerve diseases. The areas of this Special Issue are widely covered with basic studies on the molecular level regarding retinal and optic nerve diseases. Hopefully, this Special Issue will be helpful for researchers in their specific fields in scientific manners.

Dr. Toshiyuki Oshitari
Guest Editor

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Keywords

  • neurovascular unit
  • neurovascular cell death
  • neuroprotection
  • vasoprotection
  • regeneration
  • molecular and cellular pathologies
  • current and future therapies
  • drug delivery

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Published Papers (1 paper)

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Review

26 pages, 919 KiB  
Review
Translational Research and Therapies for Neuroprotection and Regeneration of the Optic Nerve and Retina: A Narrative Review
by Toshiyuki Oshitari
Int. J. Mol. Sci. 2024, 25(19), 10485; https://doi.org/10.3390/ijms251910485 - 29 Sep 2024
Viewed by 1258
Abstract
Most retinal and optic nerve diseases pose significant threats to vision, primarily due to irreversible retinal neuronal cell death, a permanent change, which is a critical factor in their pathogenesis. Conditions such as glaucoma, retinitis pigmentosa, diabetic retinopathy, and age-related macular degeneration are [...] Read more.
Most retinal and optic nerve diseases pose significant threats to vision, primarily due to irreversible retinal neuronal cell death, a permanent change, which is a critical factor in their pathogenesis. Conditions such as glaucoma, retinitis pigmentosa, diabetic retinopathy, and age-related macular degeneration are the top four leading causes of blindness among the elderly in Japan. While standard treatments—including reduction in intraocular pressure, anti-vascular endothelial growth factor therapies, and retinal photocoagulation—can partially delay disease progression, their therapeutic effects remain limited. To address these shortcomings, a range of neuroprotective and regenerative therapies, aimed at preventing retinal neuronal cell loss, have been extensively studied and increasingly integrated into clinical practice over the last two decades. Several of these neuroprotective therapies have achieved on-label usage worldwide. This narrative review introduces several neuroprotective and regenerative therapies for retinal and optic nerve diseases that have been successfully translated into clinical practice, providing foundational knowledge and success stories that serve as valuable references for researchers in the field. Full article
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