Signal Transduction and Transcriptional Regulation in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (30 March 2024) | Viewed by 2138
Special Issue Editor
Interests: transcriptional regulation; epigenetic mechanisms of gene expression regulation; signal transduction
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Signal transduction pathways concern crucial mechanisms that allow the transfer of biological information from the cell surface to various intracellular targets and from one cell to another.
They are triggered by modular proteins that regulate protein–protein interactions and the reversible assembly of numerous signaling complexes. Additionally, cell signaling transduction can control gene expression, modulating the activity of nuclear transcription factors and thus leading to changes in the cellular transcriptional program. This, at least in part, could be involved in the termination of the induction response to different extracellular stimuli and final functional organization. On the other hand, several transcription factors control specific signaling pathways by modulating the expression of the genes participating in them. This intricate and fine-coordinated network of interactions guarantees a constant and dynamic flow of intra- and inter-cellular communication. The alteration of these cell signaling events and related gene expression programs causes the onset of many pathological processes.
This Special Issue invites contributions, including original research articles, reviews, commentaries, and perspectives that could help to collect new insights into molecular underpinnings of cellular transduction signaling and the control of gene expression in physiological and pathological conditions.
Dr. Elena Cesaro
Guest Editor
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Keywords
- signaling pathway
- cell–cell communication
- intracellular signal
- transcription regulation
- histone modification
- chromatin remodeling
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