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Translational Research in Ophthalmic Pathology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 1024

Special Issue Editor


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Guest Editor
1. Department of Ocular Oncology, The Rotterdam Eye Hospital, Schiedamse Vest 180, 3011 BH Rotterdam, The Netherlands
2. Department of Pathology, Section Ophthalmic Pathology, Erasmus University Medical Center, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
3. Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Interests: ocular oncology; neuro-oncology; autoimmune periorbital disease

Special Issue Information

Dear Colleagues,

The field of ophthalmic pathology is confined to the work of a select number of ophthalmologists and pathologists worldwide. Nevertheless, structures as diverse as the eyelids, conjunctiva, orbit, and the diverse tissues of the globe, cornea, sclera, uvea, retina, lens, and optic nerve can give rise to a host of different diseases but even significant advances in the knowledge of anatomy, histology, diagnostic histopathology, pathophysiology, or (epi) genetics prove to be difficult to publish. This Special Issue, with its focus on molecular-level investigations, invites authors to submit tissue-based translational research that aims to elucidate the molecular pathophysiology of diseases of the eye and orbit. Rare as these may be, a better understanding of molecular histopathology and pathophysiology is essential for improving the diagnosis and, ultimately, treatment of patients.

Dr. Robert M. Verdijk
Guest Editor

Manuscript Submission Information

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Keywords

  • eye
  • ophthalmology
  • immunohistochemistry
  • molecular biology
  • pathophysiology
  • translational science
  • anatomy
  • histology
  • pathology
  • orbit

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Published Papers (1 paper)

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Research

17 pages, 3972 KiB  
Article
Melatonin Receptor Expression in Primary Uveal Melanoma
by Anna Hagström, Ruba Kal Omar, Hans Witzenhausen, Emma Lardner, Oran Abdiu and Gustav Stålhammar
Int. J. Mol. Sci. 2024, 25(16), 8711; https://doi.org/10.3390/ijms25168711 - 9 Aug 2024
Viewed by 773
Abstract
Melatonin, noted for its anti-cancer properties in various malignancies, including cutaneous melanoma, shows promise in Uveal melanoma (UM) treatment. This study aimed to evaluate melatonin receptor expression in primary UM and its association with UM-related mortality and prognostic factors. Immunohistochemical analysis of 47 [...] Read more.
Melatonin, noted for its anti-cancer properties in various malignancies, including cutaneous melanoma, shows promise in Uveal melanoma (UM) treatment. This study aimed to evaluate melatonin receptor expression in primary UM and its association with UM-related mortality and prognostic factors. Immunohistochemical analysis of 47 primary UM tissues showed low expression of melatonin receptor 1A (MTNR1A) and melatonin receptor 1B (MTNR1B), with MTNR1A significantly higher in patients who succumbed to UM. Analysis of TCGA data from 80 UM patients revealed RNA expression for MTNR1A, retinoic acid-related orphan receptor alpha (RORα), and N-ribosyldihydronicotinamide:quinone oxidoreductase (NQO2), but not MTNR1B or G protein-coupled receptor 50 (GPR50). Higher MTNR1A RNA levels were observed in patients with a BRCA1 Associated Protein 1 (BAP1) mutation, and higher NQO2 RNA levels were noted in patients with the epithelioid tumor cell type. However, Kaplan–Meier analysis did not show distinct survival probabilities based on receptor expression. This study concludes that UM clinical samples express melatonin receptors, suggesting a potential mechanism for melatonin’s anti-cancer effects. Despite finding higher MTNR1A expression in patients who died of UM, no survival differences were observed. Full article
(This article belongs to the Special Issue Translational Research in Ophthalmic Pathology)
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