Molecular Mechanism of Diabetic Kidney Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 November 2024 | Viewed by 3696
Special Issue Editor
2. Centre for Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, No. 2, Eftimie Murgu Sq., 300041 Timisoara, Romania
3. Centre for Cognitive Research in Neuropsychiatric Pathology (Neuropsy-Cog), Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, No. 2, Eftimie Murgu Sq., 300041 Timisoara, Romania
4. Center for Translational Research and Systems Medicine, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, No. 2, Eftimie Murgu Sq., 300041 Timisoara, Romania
5. County Emergency Hospital Timisoara, 300723 Timisoara, Romania
Interests: chronic kidney disease; diabetic kidney disease; epigenetics; proteomics; lipidomics; metabolomics; mitochondrial dysfunction
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Special Issue Information
Dear Colleagues,
Diabetic kidney disease (DKD), as a major microvascular complication of both type 1 and type 2 diabetes mellitus (DM), accounts for over 40% of patients who reach end-stage renal disease and are referred to renal replacement therapies.
The tubulocentric concept with regard to DKD has emphasized the pivotal role of the proximal tubule and of the tubulointerstitial compartment in the development of DKD. The glomerular theory raises a similar interest, with a special focus on the contribution of podocyte injury in the course of DKD.
Chronic systemic inflammation and the role of inflammatory response in the development and progression of chronic kidney disease DKD have been highly recognized.
An inflammatory response which involves the innate immune system, as well as epigenetic mechanisms, plays an important role in the development of albuminuria in the course of type 2 DM. Particular molecular signatures and epigenetic profiles have emerged to support the complexity of DKD.
Mitochondrial dysfunction plays many specific roles in the pathogenesis of DKD. The importance of mitochondria in the pathogenesis of DKD resides in both the tubulocentric view and the mitochondria-centric view. Mitochondrial injury to glomerular endothelial cells and podocytes is also important for the development of DKD.
We are particularly taking interest in original papers and reviews that report the relevance of the molecular mechanisms involved in the pathogenesis of DKD.
Prof. Dr. Ligia Petrica
Guest Editor
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Keywords
- genetics
- epigenetics
- inflammation
- mitochondrial dysfunction
- proteomics
- lipidomics
- metabolomics
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