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Adipokines as Peripheral Signals for the Integration of Energy Balance...
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Adipokines as Peripheral Signals for the Integration of Energy Balance and Reproduction

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 2169

Special Issue Editors

Dr. Roberta Lattanzi

E-Mail Website
Guest Editor
Department of Physiology and Pharmacology “Vittorio Erspamer”, University Sapienza, Rome, Italy
Interests: G protein-coupled receptor; chemokines; prokineticins; pain; neuroinflammation; in vivo and in vitro pharmacological analysis
Special Issues, Collections and Topics in MDPI journals
Dr. Rossella Miele

E-Mail Website
Guest Editor
Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, Piazzale Aldo Moro 5, I-00185 Rome, Italy
Interests: G protein-coupled receptor; signal transduction; chemokines; protein-protein interactions; yeast genetic analysis; alternative splicing; transcriptional regulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In mammals, reproductive functions are known to be tightly regulated by energy availability. Atypical weight loss or gain (obesity) negatively affects the reproductive axis. The balance between energy homeostasis and reproduction is monitored by a complex system involving the brain and a variety of peripheral tissues. This process occurs via numerous factors, including metabolic hormones and nutrients.

The aim of this Special Issue is to review emerging aspects of the role of adipokines, endocrine factors secreted primarily by white adipose tissue, in the regulation of fertility and reproduction in health, obesity and reproductive disorders.

Dr. Roberta Lattanzi
Dr. Rossella Miele
Guest Editors

Manuscript Submission Information

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Keywords

  • adipokines
  • obesity
  • fertility
  • reproduction
  • hypothalamic–pituitary–gonadal axis

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Published Papers (2 papers)

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14 pages, 2387 KiB  
Article
MRAP2a Binds and Modulates Activity and Localisation of Prokineticin Receptor 1 in Zebrafish
by Maria Rosaria Fullone, Daniela Maftei, Martina Vincenzi, Roberta Lattanzi and Rossella Miele
Int. J. Mol. Sci. 2024, 25(14), 7816; https://doi.org/10.3390/ijms25147816 - 17 Jul 2024
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Abstract
The prokineticin system plays a role in hypothalamic neurons in the control of energy homeostasis. Prokineticin receptors (PKR1 and PKR2), like other G-protein-coupled receptors (GPCRs) are involved in the regulation of energy intake and expenditure and are modulated by the accessory membrane protein [...] Read more.
The prokineticin system plays a role in hypothalamic neurons in the control of energy homeostasis. Prokineticin receptors (PKR1 and PKR2), like other G-protein-coupled receptors (GPCRs) are involved in the regulation of energy intake and expenditure and are modulated by the accessory membrane protein 2 of the melanocortin receptor (MRAP2). The aim of this work is to characterise the interaction and regulation of the non-melanocortin receptor PKR1 by MRAP2a in zebrafish (zMRAP2a) in order to use zebrafish as a model for the development of drugs targeting accessory proteins that can alter the localisation and activity of GPCRs. To this end, we first showed that zebrafish PKR1 (zPKR1) is able to interact with both zMRAP2a and human MRAP2 (hMRAP2). This interaction occurs between the N-terminal region of zPKR1 and the C-terminal domain of zMRAP2a, which shows high sequence identity with hMRAP2 and a similar propensity for dimer formation. Moreover, we demonstrated that in Chinese hamster ovary (CHO) cells, zMRAP2a or hMRAP2 are able to modulate zPKR1 activation induced by zebrafish PK2 (zPK2) resulting in an impaired ERK and STAT3 activation. Full article
(This article belongs to the Special Issue Adipokines as Peripheral Signals for the Integration of Energy Balance and Reproduction)
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13 pages, 2823 KiB  
Article
Yeast Hydrolysate Inhibits Lipid Accumulation via Regulation of Lipid Accumulation-Related Genes in a Drosophila Model of High-Sugar Diet-Induced Obesity
by Nari Kim, Yejin Ahn, Kayoung Ko, Boyun Kim, Kisoo Han, Hyung Joo Suh, Jewon Jung and Ki-Bae Hong
Int. J. Mol. Sci. 2023, 24(22), 16302; https://doi.org/10.3390/ijms242216302 - 14 Nov 2023
Viewed by 1318
Abstract
The increasing frequency of processed food consumption has led to the higher ingestion of sugar, increasing the risk of chronic diseases, such as obesity. Yeast hydrolysates (YHs) inhibit body fat accumulation. However, the action mechanism of YH in relation to high-sugar diet-induced obesity [...] Read more.
The increasing frequency of processed food consumption has led to the higher ingestion of sugar, increasing the risk of chronic diseases, such as obesity. Yeast hydrolysates (YHs) inhibit body fat accumulation. However, the action mechanism of YH in relation to high-sugar diet-induced obesity is still unclear. Therefore, this study aimed to evaluate the biological effects of YH on lipid accumulation and verify behavioral changes and carbohydrate metabolic gene regulation in high-sugar diet-fed fruit flies. Adult male flies (Drosophila melanogaster; 2–5 days old) were exposed to 20% sucrose for obesity induction. In high-sugar-fed Drosophila, the effect of YH was compared with that of yeast extract. The effects of YH on body conditions and lipid droplet size were quantified and analyzed. Behavioral factors were evaluated by analyzing circadian rhythm patterns and neurotransmitter content, and a molecular approach was used to analyze the expression of metabolism-related genes. Dietary supplementation with YH did not reduce total sugar content, but significantly decreased the triglyceride (TG) levels in Drosophila. A behavioral analysis showed that the total number of night-time activities increased significantly with YH treatment in a dose-dependent manner. In addition, YH effectively regulated the gene expression of insulin-like peptides related to carbohydrate metabolism as well as genes related to lipogenesis. The TG content was significantly reduced at a YH concentration of 0.5%, confirming that the active compound in YH effectively suppresses fat accumulation. These findings support that YH is a potential anti-obesity food material via regulating carbohydrate metabolism in Drosophila. Full article
(This article belongs to the Special Issue Adipokines as Peripheral Signals for the Integration of Energy Balance and Reproduction)
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