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Recent Nanotechnology in Drug Delivery
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Recent Nanotechnology in Drug Delivery

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 383

Special Issue Editor

Prof. Dr. Omar Mertins

E-Mail Website
Guest Editor
Laboratory of Nano Bio Materials, Department of Biophysics, Paulista Medical School, Federal University, São Paulo 04023-062, Brazil
Interests: nanoparticles; liposomes; cubosomes; biopolymers; drug delivery; giant vesicles; lipid membranes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Drug delivery nanotechnology has achieved high levels in clinical trials and practical applications in human and veterinary medicine. Currently, research on nano delivery systems focuses on improved and functional nanoparticles and nanomaterials designed to provide effective drug and bioactive targeting, enable gene therapies, and optimize complex treatments.

This Special Issue aims to provide a current and recent overview of basic research, developmental studies, and applications of drug delivery systems in all fields related to human and veterinary medicine. Special focus will be given to nanotechnological approaches. In addition, clinical or pure model submissions with biomolecular experiments are welcomed.

Experimental, theoretical, and review articles are welcome.

This Special Issue is supervised by Prof. Dr. Omar Mertins, with assistance from Prof. Dr. Patrick D. Mathews (Sao Paulo State University, Email: ). 

Prof. Dr. Omar Mertins
Guest Editor

Prof. Dr. Patrick D. Mathews
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • smart nanoparticles
  • hybrid nanomaterial
  • functionalization
  • drug targeting
  • liposome
  • cubosome
  • polypeptide
  • polymers
  • biomolecules
  • cancer
  • vaccine
  • antimicrobial
  • antiparasite
  • antioxidant
  • immunomodulatory
  • genetic therapy
  • nanomedicine

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Published Papers (1 paper)

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17 pages, 5177 KiB  
Article
Iron-Doped Hydroxyapatite Nanoparticles for Magnetic Guided siRNA Delivery
by Hina Inam, Lorenzo Degli Esposti, Federico Pupilli, Marta Tavoni, Francesca Casoli, Simone Sprio and Anna Tampieri
Int. J. Mol. Sci. 2025, 26(16), 7712; https://doi.org/10.3390/ijms26167712 - 9 Aug 2025
Viewed by 254
Abstract
Small interfering RNAs (siRNAs) are particularly attractive among the frontier drugs due to their high specificity of action, activity on disease-inducing genes, and small molecular weight, thus being one of the most studied agents for gene therapy. However, siRNAs are prone to fast [...] Read more.
Small interfering RNAs (siRNAs) are particularly attractive among the frontier drugs due to their high specificity of action, activity on disease-inducing genes, and small molecular weight, thus being one of the most studied agents for gene therapy. However, siRNAs are prone to fast enzymatic degradation in the bloodstream, as well as other limitations that challenge their clinical translation. Nanoparticle (NP) delivery of siRNA has been proposed as a potential solution, overcoming their intrinsic limitations. In this regard, the siRNA delivery by magnetic nanoparticles is of particular interest because, being susceptible to external magnetic fields, it may be guided remotely, maximizing transfection efficiency and minimizing side effects. In addition, magnetic NPs would also allow a theranostic combination of drug delivery, magnetic resonance imaging, and hyperthermia. In this work we have studied the uptake of a model therapeutic siRNA by iron-doped hydroxyapatite nanoparticles (FeHA NPs), which are known to have excellent biocompatibility and magnetic susceptibility. We discovered that FeHA NPs stabilized by citrate (Cit-FeHA NPs) uptake siRNA by adsorption quickly and with high efficiency (ca. 90%) without altering nanoparticles physicochemical properties or colloidal stability. SiRNA-loaded Cit-FeHA NPs are able to slowly release their payload, with a sustained release of 45 days without siRNA degradation. Our work is therefore the preliminary validation of the suitability of FeHA NPs for magnetically guided delivery of therapeutic siRNAs. Full article
(This article belongs to the Special Issue Recent Nanotechnology in Drug Delivery)
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